No abstract

No abstract

No abstract

Supramolecular adducts obtained by interaction between the anionic porphyrin meso-tetrakis(4-carboxyphenyl)porphyrin (TPPC) or its zinc(II) derivative (ZnTPPC) with a biocompatible amino-terminated polypropylene or poly(ethylene oxide)s (Jeffamines) has been investigated. The interaction with the polymer allows the stabilization of the porphyrins in their monomeric form under physiological conditions. The photodynamic properties of the supramolecular adducts were explored by typical 1O2 indirect detection. Their photodynamic action were evaluated in vitro using human red blood cells (HRBCs) under different experimental conditions. The morphology of erythrocytes was investigated by optical microscopy after incubation with porphyrin compounds and light irradiation. The images show loss of their normal biconcave profile and an incoming spiny configuration with blebs evident on their surfaces.

No abstract

St. John's Wort (SJW) has been intensively studied in the last years with respect to its pharmacological properties and to understand the mechanism of action of its bioactive compounds. In fact, it is currently used for the treatment of several disorders. Nevertheless, only recently nanotechnology has been applied for the delivery of SJW extract in vivo, to enhance its neuroprotective properties. In the present review, the advantages, the chemical characterization and the special biological features of SJW extract are discussed, underlining the potential use of nanotechnology in the development of drug carrier systems based on lipid nanoparticles. A special focus is given to solid lipid nanoparticles (SLN) and to nanostructured lipid carriers (NLC) given their versatility for a wide range of bioactive compounds.

No abstract