Refractory or recurrent infections of skin, nails, and the mucous membranes are clinical signs of chronic mucocutaneous candidiasis, frequently associated with immunological defects. Here we describe a 39-years-old female patient, with familial CMC, that presented with an extensive infection caused by an azole-resistant Candida albicans isolate, successfully treated with posaconazole.
Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis\ud
of unknown aetiology, characterized by primarily\ud
sterile, painful ulcers with typical violaceous undermined\ud
borders and mucopurulent or haemorrhagic exudate. PG is\ud
commonly associated with other systemic disorders. Diagnosis\ud
of primary idiopathic forms is reached following the\ud
exclusion of inflammatory bowel disease (IBD), rheumatic\ud
disorders, monoclonal gammopathy and solid tumours\ud
(1, 2). Treatment is generally based on corticosteroid and\ud
immunosuppressive therapy; however, the recent use of\ud
biological drugs has shown their effectiveness
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