No abstract

The prevalence of patients hospitalized in ICUs with COVID-19 and co-infected by pathogenic bacteria is relevant in this study, considering the integrality of treatment. This systematic review assesses the prevalence of co-infection in patients admitted to ICUs with SARS-CoV-2 infection, using the PRISMA guidelines. We examined the results of the PubMed, Embase, and SciELO databases, searching for published English literature from December 2019 to December 2021. A total of 542 rec ords were identified, but only 38 were eligible and, and of these only 10 were included. The tabulated studies represented a sample group of 1394 co-infected patients. In total, 35%/138 of the patients were co-infected with Enterobacter spp., 27% (17/63) were co-infected with methicillin-sensitive Staphylococ cus aureus, 21% (84/404) were co-infected with Klebsiella spp., 16% (47/678) of patients were co-infected with coagulase-negative Staphylococcus, 13% (10/80) co-infected with Escherichia coli (ESBL), and 3% (30/1030) of patients were co-infected with Pseudomonas aeruginosa. The most common co-infections were related to blood flow; although in the urinary and respiratory tracts of patients Streptococcus pneumoniae was found in 57% (12/21) of patients, coagulase negative Staphylococcus in 44% (7/16) of patients, and Escherichia coli was found in 37% (11/29) of patients. The present research demonstrated that co-infections caused by bacteria in patients with COVID-19 are a concern.

Diarrhea is an important cause of hospitalization among infants. There are many complex factors that influence hospital use: socioeconomic and cultural characteristics, access, medical needs, and supply. The objective was to measure hospitalization rates from diarrhea among infants in Rio de Janeiro in 1996 and the association with demographic, geographical, and clinical data comparing differentials between public/university and private/philanthropic hospital care under the Unified National Health System (SUS). The authors used data from the Hospital Information System. Private/philanthropic hospitals admitted approximately four times more children than public/university hospitals. Analysis shows that variation in age, length of hospital stay, and use of pediatric intensive care may reflect differences in physicians' practice styles. This may in turn influence the respective health care unit's capacity to prevent death associated with diarrhea. The authors conclude that it is necessary to continue the analysis of hospital utilization under the SUS due to implications for the cost and quality of pediatric care. Resumo A diarréia é causa de hospitalização importante entre os menores de um ano, sendo influenciada por múltiplos e complexos fatores, tais como, sociais, econômicos, culturais, além de necessidades médicas e seu tipo de financiamento. O objetivo deste trabalho foi o de medir a taxa de hospitalização de diarréia infantil no Rio de Janeiro, em 1996, e a associação com infor-mações demográficas, geográficas e clínicas, cotejando diferenças entre hospitais públicos/uni-versitários e contratados/filantrópicos do Sistema Único de Saúde (SUS). Os dados do estudo fo-ram provenientes do Sistema de Informação Hospitalar. Os estabelecimentos contratados/filan-trópicos admitem cerca de quatro vezes mais crianças do que os públicos/universitários. As va-riações observadas quanto à idade das crianças internadas, o tempo e custos médios de interna-ção e a utilização da Unidade de Tratamento Intensivo podem refletir diferenças na conduta médica, e por conseguinte, na capacidade do serviço em evitar o óbito por diarréia das crianças internadas. Conclui-se que é necessário monitorar, de forma contínua, a utilização dos recursos hospitalares, para atuar diretamente nos custos e na qualidade da assistência prestada.

A cDNA encoding the N-acetyl-beta-D-glucosaminidase (NAG) protein of Paracoccidioides brasiliensis, Pb NAG1, was cloned and characterized. The 2663-nucleotide sequence of the cDNA consisted of a single open reading frame encoding a protein with a predicted molecular mass of 64.73 kDa and an isoeletric point of 6.35. The predicted protein includes a putative 30-amino-acid signal peptide. The protein as a whole shares considerable sequence similarity with 'classic' NAG. The primary sequence of Pb NAG1 was used to infer phylogenetic relationships. The amino acid sequence of Pb NAG1 has 45, 31 and 30% identity, respectively, with homologous sequences from Trichoderma harzianum, Aspergillus nidulans and Candida albicans. In particular, striking homology was observed with the active site regions of the glycosyl hydrolase group of proteins (family 20). The expected active site consensus motif G X D E and catalytic Asp and Glu residues at positions 373 and 374 were found, reinforcing that Pb NAG1 belongs to glycosyl hydrolase family 20. The nucleotide sequence of Pb nag1 and its flanking regions have been deposited, along with the amino acid sequence of the deduced protein, in GenBank under accession number AF419158.

No abstract

-Regular physical exercise tends to benefit people with fibromyalgia syndrome (FMS). The effects have been observed regarding aerobic power and strength; however, results concerning flexibility have been controversial. In general, studies have evaluated specific joints or tests involving only a single body movement. The aim of this study was to compare the flexibility profile of FMS and asymptomatic women using a more comprehensive test protocol regarding the number of movements and joints involved. The sample consisted of 30 women divided into two groups: asymptomatic (n = 15; mean age: 50.2 ± 8.2 years; mean weight: 63.0 ± 9.6 kg; mean height: 157 ± 6 cm) and fibromyalgia (n = 15; mean age: 47.3 ± 9.4 years; mean weight: 61.9 ± 12.2 kg; mean height: 159 ± 7 cm). Flexibility was measured using the Flexitest, which was evaluated by the global index of flexibility (Flexindex), and the five indices of variability of joint mobility: intermovement (IVIM), interjoint (IVIA), flexion-extension (IVFE), between segment (IVES) and distal-proximal (IVDP). All of the indices were calculated based on the results of the 20 movements of the Flexitest. There was no difference between groups (44.4 ± 3.7 vs. 45.7 ± 4.1 points, for asymptomatic and fibromyalgia, respectively; p = 0.379; 95% confidence interval (CI): -4.2 to 1.6). Most of the sample (83%) showed an average level of flexibility based on reference values for gender and age. Only IVIM showed a significant difference between the groups. Asymptomatic and fibromyalgic women have similar overall levels of flexibility but with different profiles. Key words: Chronic pain; Joints; Range of motion. (n = 15; 50,2 ± 8,2 anos; 63,0 ± 9,6 kg; 157 ± 6 cm) e fibromiálgicas (n = 15; 47,3 ± 9,4 anos; 61,9 ± 12,2 kg; 159 ± 7 (44,4 ± 3,7 vs 45,7 ± 4,1 pontos, para assintomáticas e fibromiálgicas respectivamente; p=0,379;2 a 1,6 Resumo -Exercícios físicos em mulheres com síndrome de fibromialgia (SFM) têm apresentado efeitos na força e potência aeróbica, contudo, os resultados acerca da flexibilidade têm sido controversos. Além disso, os estudos têm avaliado articulações específicas ou testes que envolvam apenas um único movimento corporal. Objetivou-se comparar o perfil de flexibilidade global de mulheres acometidas pela SFM e assintomáticas a partir de um protocolo de teste mais abrangente quanto ao número de movimentos e articulações envolvidas. Participaram da pesquisa 30 mulheres divididas em dois grupos: assintomáticas cm). A flexibilidade medida pelo Flexiteste foi avaliada pelo índice global de flexibilidade (flexíndice) e pelos cinco índices de variabilidade da mobilidade articular: intermovimentos (IVIM), intra-articulação (IVIA), flexão-extensão (IVFE), entre segmentos (IVES) e distal-proximal (IVDP). Todos os índices foram calculados com base nos resultados dos 20 movimentos do flexiteste. Não houve diferença no flexíndice entre os grupos

No abstract

No abstract