Given the current importance of publishing medical research articles in high-impact international journals, this article briefly presents key moments in the evolution of this reporting genre for a better understanding of the diachronic changes that have shaped it into a highly useful tool for creating and spreading knowledge, as well as for establishing academic hierarchies at both individual and institutional level. Therefore, focus will be placed not only on the evolution of its structure and purpose, but also on issues such as knowledge construction, knowledge claims, writer-reader interaction and the appropriate writing conventions and rhetorical strategies required for successful scientific communication.

Stroke occurrence is not randomly distributed over time but has circadian rhythmicity with the highest frequency of onset in the morning hours. This specific temporal pattern is valid for all subtypes of cerebral infarction and intracerebral hemorrhage. It also correlates with the circadian variation of some exogenous factors such as orthostatic changes, physical activity, sleep-awake cycle, as well as with endogenous factors including dipping patterns of blood pressure, or morning prothrombotic and hypofibrinolytic states with underlying cyclic changes in the autonomous system and humoral activity. Since the internal clock is responsible for these circadian biological changes, its disruption may increase the risk of stroke occurrence and influence neuronal susceptibility to injury and neurorehabilitation. This review aims to summarize the literature data on the circadian variation of cerebrovascular events according to physiological, cellular, and molecular circadian changes, to survey the available information on the chronotherapy and chronoprophylaxis of stroke and its risk factors, as well as to discuss the less reviewed impact of the circadian rhythm in stroke onset on patient outcome and functional status after stroke.

Recent knowledge concerning the role of non-coding RNAs (ncRNAs) in myocardial ischemia/reperfusion (I/R) injury provides new insight into their possible roles as specific biomarkers for early diagnosis, prognosis, and treatment. MicroRNAs (miRNAs) have fewer than 200 nucleotides, while long ncRNAs (lncRNAs) have more than 200 nucleotides. The three types of ncRNAs (miRNAs, lncRNAs, and circRNAs) act as signaling molecules strongly involved in cardiovascular disorders (CVD). I/R injury of the heart is the main CVD correlated with acute myocardial infarction (AMI), cardiac surgery, and transplantation. The expression levels of many ncRNAs and miRNAs are highly modified in the plasma of MI patients, and thus they have the potential to diagnose and treat MI. Cardiomyocyte and endothelial cell death is the major trigger for myocardial ischemia–reperfusion syndrome (MIRS). The cardioprotective effect of inflammasome activation in MIRS and the therapeutics targeting the reparative response could prevent progressive post-infarction heart failure. Moreover, the pharmacological and genetic modulation of these ncRNAs has the therapeutic potential to improve clinical outcomes in AMI patients.

Music has been proven to have therapeutic potential in neurological disorders, especially Parkinson’s disease (PD), since rhythmic auditory cueing can partially replace the progressive loss of rhythmicity and automaticity. Several reports have highlighted improvements in motor outcomes in PD patients undergoing music therapy, but only a few studies have evaluated non-motor outcomes, such as quality of life (QoL), which deteriorates with disease progression. The current pilot study aims to examine the effects of a multimodal rehabilitation program centered on physical therapy combined with listening to music on self-reported QoL in people with PD, compared to the same rehabilitation program alone. The study was conducted on patients with idiopathic PD who attended a specific rehabilitation program with a duration of 2.5 h daily for 14 days. The patients were divided into the study group (16 patients), who listened to background music during the rehabilitation program sessions, and the control group who did not listen to music during sessions. The patients were assessed using the self-report Parkinson’s Disease Questionnaire (PDQ-39) at the beginning of the program and 1 month after its initiation. The patients in the study group registered greater improvements in five of the eight areas of life assessed by PDQ-39 compared to the control group. In conclusion, listening to music combined with a multimodal rehabilitation program centered on physical therapy may be beneficial for the patients’ quality of life.

Colorectal cancer remains one of the most frequent malignancies (third place at both genders) worldwide in the last decade, owing to significant changes in modern dietary habits. Approximately half of the patients develop metastases during the course of their disease. The available therapeutic armamentarium is constantly evolving, raising questions regarding the best approach for improving survival. Bevacizumab remains one of the most widely used therapies for treating metastatic colorectal cancer and can be used after progression. This study aimed to identify the best chemotherapy partner for bevacizumab after progression. We performed a retrospective analysis of patients with metastatic colorectal cancer who were treated with bevacizumab as first- and second-line chemotherapy. Data were collected for 151 patients, 40 of whom were treated with double-dose bevacizumab after the first progression. The two standard chemotherapy regimens combined with bevacizumab were FOLFIRI/CAPIRI and FOLFOX4/CAPEOX. The initiation of first-line treatment with irinotecan-based chemotherapy improved progression-free survival and time to treatment failure but not overall survival. After the first progression, retreatment with the same regimen as that used in the induction phase was the best approach for improving overall survival (median overall survival: 46.5 vs. 27.0 months for the same vs. switched strategy, respectively). No correlations were observed between the dose intensity of irinotecan, oxaliplatin, 5-fluorouracil, or bevacizumab and the overall survival, progression-free survival in the first-/second-line treatment, and time to treatment failure. Interaction between an irinotecan-based regimen as a second-line treatment and double-dose bevacizumab after progression was associated with an improved overall survival (p = 0.06). Initiating systemic treatment with an irinotecan-based regimen in combination with bevacizumab improved the progression-free survival in the first-line treatment and time to treatment failure. In terms of overall survival, bevacizumab treatment after the first progression is better partnered with the same regimen as that used in the induction phase.

The optimal MDFV model was able to explain approximately 96% of the total variance in the estrogenic binding relative affinity of triphenyl acrylonitriles and to have estimation and prediction abilities. Although there were no significant differences in terms of goodness-of-fit, the MDFV model proved to exhibit better information parameters compared to the previously reported model using the same number of molecular descriptors.

Structure/Activity/Property Relationships (SARs, SPRs, and PARs) appears with the studies of Louis Plack HAMMETT in 1937 [1]. The most important applications of Hammett's equation were summarized in [2].Quantitative relationships (QSAR, QSPR, QPAR) occur when the property/activity is quantitative. Not all properties and activities of chemical compounds can be classified as quantitative. In fact, few properties meet all theoretical requirements to be quantitative [3]. From this reason in the last time are avoided to be used QSAR, QSPR, and QPAR, in their place being used (Q)SAR, (Q)SPR, and (Q)PAR, or more simple SAR, SPR, and PAR. Structure-based approaches have two levels (topological and geometrical). In the topological based level, an atom, a bond from a molecule can exist (and then are evidenced through electronic transitions and/or molecular vibrations and/or rotations) or not (being a matter of 0 and 1). Not so simple stays things related to molecular geometry (especially on liquid or gas phases). Heisenberg uncertainly principle [4] shows the uncertainly rules presented at micro level (molecular and atomic level). More than that, molecular geometry depends on the environment where the molecule is (vicinity of the molecule), temperature, pressure, so on, thus dealing with molecular geometry is both a matter of relativity and a matter of uncertainty. Thus, Structure-Property-Activity Relationships (SPARs) must deal with certainties (such as molecular topology), uncertainties (such as molecular geometry), relativities (such as biological activities) and evidences (such as physical and chemical quantitative properties MATERIALS:The hydrophobicity on Hessa et al. scale [ 10 ] of fifteen standard amino acids was the property of interest.The experimental values of hydrophobicity were as follows: alanine (0.11), asparagine (2.05), aspartate (3.49), cysteine (-0.13), glutamine (2.36), glutamate (2.68), glycine (0.74), isoleucine (-0.6), leucine (-0.55), lysine (2.71), methionine (-0.1), phenylalanine (-0.32), serine (0.84), threonine (0.52), and valine (-0.31). MDF-SPAR completion: MDF Calculator & MDF Predictor. RESULTS:The model with one and two descriptors, respectively proved to has estimated and predictive abilities: Ŷ mono =-0.58+iMDRoQg·8.53 Eq(1) Ŷ bi =-1.36+iMDRoQg·6.03+ISPDwQg·0.08 Eq(2) The application of the parameters presented in the table bellow leads to the results presented bellow: Param.Eq (1) Eq (2) o building (with HyperChem) of topological (2D) and geometrical (3D) through same choices as were build the selected set to obtain predicted value(s) for the property / activity of the new compounds, even if this (these) compound (s) were not yet synthesized, in order to see if the new structure (virtual compound at this time) has or not improvements in desired property/activity. CONCLUSION MDF method and MDF-SAR methodology proved to be a very good tool for design of chemical compounds.(6) MDF Calculator (7) MDF Predictor ACKNOWLEDGEMENTS: [MDF] The MDF project was supported through ET36 resear...

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