The coronavirus disease 2019 (COVID-19) pandemic has been emerged as a global health emergency with consequences of magnitude both at health, social, and economy level. According to the World Health Organization (WHO), as for May 25, 2021, more than 167,000,000 confirmed COVID-19 cases have been confirmed, including 3,472,068 deaths. 1 Several risk factors, both modifiable and nonmodifiable, could influence the susceptibility of acquiring severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The severity of the symptoms among infected patients varies considerably from being asymptomatic to developing a critical illness with lethal complications, and some genetic and clinical characteristics of patients have been proposed as determinants of poor outcomes. 2 SARS-CoV-2 uses the angiotensin-converting enzyme 2 (ACE2) receptor for cell entry, and thus it has been suggested that host genetic factors may play a role in susceptibility to COVID-19. According to published evidence, people with ACE2 polymorphism who have type 2 transmembrane serine proteases (TMPRSS2) would be at a higher risk of SARS-CoV-2 infection. In addition, patients possessing HLA-B*15:03 genotype may become immune to the infection. 3

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