GS was common in IBD and associated with having had a recent flare. GS may be transient for some patients, whereby dietary recommendations during and after a flare could focus on the avoidance of specific food triggers with possible reintroduction of these foods over time. This study prompts further prospective investigation into the temporal evolution of GS in IBD.
Inflammatory bowel disease (IBD) is a chronic disorder that includes Crohn disease and ulcerative colitis. The disorder is characterized by relapsing and remitting inflammation of the gastrointestinal tract and a high risk for complications, surgeries, and frequent hospitalizations (Peyrin-Biroulet et al., 2016). The prevalence of IBD among adults in the United States (U.S.) was estimated to be 1.3% of the population (3 million) in 2015 and exceeded 0.3% (10 millions) in
Chronic starvation and refeeding have been associated with liver injury (LI). We present a patient with anorexia nervosa who exhibited both phenomena of malnutrition-related LI. At presentation, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were elevated at 154 and 136 U/L, respectively, and rose rapidly to peaks of 750 and 638 U/L, respectively, as nutrition was introduced. Mechanisms of starvation-related LI include impaired degradation and secretion of lipids, as well as starvation-induced autophagy. LI during refeeding may be related to rapid increase in glucose availability. These phenomena are crucial to consider in patients with chronic starvation undergoing refeeding.
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