Two Acute Liver Injuries in a Patient With Malnutrition

Su, Amanda; Choe, Monica; Birkness, Jacqueline E.; Limketkai, Berkeley N.; Chen, Po-Hung

doi:10.14740/jmc3713

Cited by 1 publication

(2 citation statements)

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“…Chronic starvation induces changes in the liver, such as a reduced liver fat content and a reduction in hepatic glycogen and mucins stained by PAS staining. These findings are consistent with observations of depleted glycogen stores in the livers of AN patients [ 23 ]. As short-term starvation did not result in significant changes, we suggest that there was a gradual depletion of liver fat stores due to the prolonged period of starvation.…”

Section: Discussionsupporting

confidence: 93%

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Starvation in Mice Induces Liver Damage Associated with Autophagy

Schuster,

Staffeld,

Zimmermann

et al. 2024

Nutrients

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Anorexia nervosa (AN) induces organ dysfunction caused by malnutrition, including liver damage leading to a rise in transaminases due to hepatocyte damage. The underlying pathophysiology of starvation-induced liver damage is poorly understood. We investigate the effect of a 25% body weight reduction on murine livers in a mouse model and examine possible underlying mechanisms of starvation-induced liver damage. Female mice received a restricted amount of food with access to running wheels until a 25% weight reduction was achieved. This weight reduction was maintained for two weeks to mimic chronic starvation. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were measured spectrophotometrically. Liver fat content was analyzed using an Oil Red O stain, and liver glycogen was determined using a Periodic acid–Schiff (PAS) stain. Immunohistochemical stains were used to investigate macrophages, proliferation, apoptosis, and autophagy. Starvation led to an elevation of AST and ALT values, a decreased amount of liver fat, and reduced glycogen deposits. The density of F4/80+ macrophage numbers as well as proliferating KI67+ cells were decreased by starvation, while apoptosis was not altered. This was paralleled by an increase in autophagy-related protein staining. Increased transaminase values suggest the presence of liver damage in the examined livers of starved mice. The observed starvation-induced liver damage may be attributed to increased autophagy. Whether other mechanisms play an additional role in starvation-induced liver damage remains to be investigated.

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Section: Discussionsupporting

confidence: 93%

“…The following supporting information can be downloaded at , Table S1: Investigations of liver damage in AN patients [ 2 , 3 , 4 , 5 , 6 , 23 , 24 , 26 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 ]. M = Male; F = Female; NR = Not reported; Number of male patients given in brackets.…”

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confidence: 99%