Risk behaviors such as substance use or deviance are often limited to the early stages of the life course. Whereas the onset of risk behavior is well studied, less is currently known about the decline and timing of cessation of risk behaviors of different domains during young adulthood. Prevalence and longitudinal developmental patterning of alcohol use, drinking to the point of drunkenness, smoking, cannabis use, deviance, and HIV-related sexual risk behavior were compared in a Swiss community sample (N = 2,843). Using a longitudinal cohort-sequential approach to link multiple assessments with 3 waves of data for each individual, the studied period spanned the ages of 16 to 29 years. Although smoking had a higher prevalence, both smoking and drinking up to the point of drunkenness followed an inverted U-shaped curve. Alcohol consumption was also best described by a quadratic model, though largely stable at a high level through the late 20s. Sexual risk behavior increased slowly from age 16 to age 22 and then remained largely stable. In contrast, cannabis use and deviance linearly declined from age 16 to age 29. Young men were at higher risk for all behaviors than were young women, but apart from deviance, patterning over time was similar for both sexes. Results about the timing of increase and decline as well as differences between risk behaviors may inform tailored prevention programs during the transition from late adolescence to adulthood.

Aims: To investigate pathways through which momentary negative affect and depressive symptoms affect lapse risk. Design: Ecological Momentary Assessment was carried out during two weeks after an unassisted smoking cessation attempt. A three-month follow-up measured smoking frequency. Setting: Data were collected via mobile devices in German-speaking Switzerland. Participants: A total of 242 individuals (age 20-40, 67% men) reported 7,112 observations. Measurements: Online surveys assessed baseline depressive symptoms and nicotine dependence. Real-time data on negative affect, physical withdrawal symptoms, urge to smoke, abstinence-related self-efficacy, and lapses. Findings: Two-level structural equation model suggested that on the situational level, negative affect increased the urge to smoke and decreased self-efficacy ( = .20;  = -.12, respectively), but had no direct effect on lapse risk. A higher urge to smoke ( = .09) and lower self-efficacy ( = -.11) were confirmed as situational antecedents of lapses. Depressive symptoms at baseline were a strong predictor of a person's average negative affect ( = .35, all p <.001). However, the baseline characteristics influenced smoking frequency three months later only indirectly, through influences of average states on the number of lapses during the quit attempt. Conclusions:Controlling for nicotine dependence, higher depressive symptoms at baseline were strongly associated with higher average negative affect during the smoking cessation attempt, which in turn were associated with a worse longer-term outcome. Negative affect experienced during the quit attempt was the only pathway through which the baseline depressive symptoms were associated with a reduced self-efficacy and increased urges to smoke, all leading to the increased probability of lapses.

Background Expert psychiatrists conducting work disability evaluations often disagree on work capacity (WC) when assessing the same patient. More structured and standardised evaluations focusing on function could improve agreement. The RELY studies aimed to establish the inter-rater reproducibility (reliability and agreement) of ‘functional evaluations’ in patients with mental disorders applying for disability benefits and to compare the effect of limited versus intensive expert training on reproducibility. Methods We performed two multi-centre reproducibility studies on standardised functional WC evaluation (RELY 1 and 2). Trained psychiatrists interviewed 30 and 40 patients respectively and determined WC using the Instrument for Functional Assessment in Psychiatry (IFAP). Three psychiatrists per patient estimated WC from videotaped evaluations. We analysed reliability (intraclass correlation coefficients [ICC]) and agreement (‘standard error of measurement’ [SEM] and proportions of comparisons within prespecified limits) between expert evaluations of WC. Our primary outcome was WC in alternative work (WC alternative.work ), 100–0%. Secondary outcomes were WC in last job (WC last.job ), 100–0%; patients’ perceived fairness of the evaluation, 10–0, higher is better; usefulness to psychiatrists. Results Inter-rater reliability for WC alternative.work was fair in RELY 1 (ICC 0.43; 95%CI 0.22–0.60) and RELY 2 (ICC 0.44; 0.25–0.59). Agreement was low in both studies, the ‘standard error of measurement’ for WC alternative.work was 24.6 percentage points (20.9–28.4) and 19.4 (16.9–22.0) respectively. Using a ‘maximum acceptable difference’ of 25 percentage points WC alternative.work between two experts, 61.6% of comparisons in RELY 1, and 73.6% of comparisons in RELY 2 fell within these limits. Post-hoc secondary analysis for RELY 2 versus RELY 1 showed a significant change in SEM alternative.work (− 5.2 percentage points WC alternative.work [95%CI − 9.7 to − 0.6]), and in the proportions on the differences ≤ 25 percentage points WC alternative.work between two experts ( p = 0.008). Patients perceived the functional evaluation as fair (RELY 1: mean 8.0; RELY 2: 9.4), psychiatrists as useful. Conclusions Evidence from non-randomised studies suggests that intensive training in functional evaluation may increase agreement on WC between experts, but fell short to reach stakeholders’ expectations. It did not alter reliability. Isolated efforts in training psychiatrists may not suffice to reach the expected level of agreement. A societal discussion about achievable goals and readiness to consider procedural changes in WC evaluations may deserve considerations. Electron...

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