Background and Aims: Hemoglobinopathies and thalassemias are the commonest single gene disorders in India. In Terai region of India, Hemoglobinopathies and thalassemias are the most common in the Tharu community. Therefore, in this study, we aim to evaluate the Hb variant analysis of hemoglobinopathies and thalassemias in a Tharu population in Lakhimpur Kheri Districts of Uttar Pradesh, India. Materials and Methods: Total 493 individuals were recruited in this study. The demographic details and blood samples were collected from different location at Kheri district during mega health camp. Hb variant analysis was performed by high performance liquid chromatography (HPLC) system beta thalassemia short program in BIO-RAD VARIANT. Results: Out of 493, 108 (21.9%) individual suffers with abnormal haemoglobinopathies. In which β-thalassemia trait is the commonest haemoglobinopathy (12.98%), followed by HbE trait (7.50%), and compound heterozygous HbS/β-Thalassemia trait (1.42%) in overall population. The HbF was significantly greater in HbS heterozygous (1.45 ± 1.41), whereas mean HbA2 was significantly greater in β-Thalassemia trait (5.17 ± 1.36). Conclusion: The high incidence of hemoglobinopathies and thalassemias were observed in Tharu community in Lakhimpur Kheri districts of Uttar Pradesh, Indian.
PurposeTo evaluate the impact of voiding position on uroflowmetry parameters and to assess its potential clinical implications.Materials and MethodsWe conducted a prospective study from 2013 to 2015 and included men between 18 and 77 years old who were either healthy volunteers with an International Prostate Symptom Score (IPSS) ≤7 or men with benign prostate enlargement that were on alpha-blocker medication and had an IPSS <10. Participants underwent uroflowmetry and post-void residual urine (PVRU) measurements twice, once in a sitting position and once in a standing position. The participants were divided into 4 groups based on age (35 years or younger, 36 to 50 years, 51 to 60 years, and older than 60 years).ResultsA total of 740 men with a mean age of 40.35 years were evaluated. There was no significant difference in uroflowmetry parameters until the age of 50 years between the voiding positions. However, in those older than 50 years, PVRU volume was significantly lower in the sitting position than the standing position, whereas voiding time was significantly higher in the sitting position than the standing position. Other uroflowmetry parameters, including maximal and average urine flow rates, were non-significant.ConclusionsThe voiding position plays an important role in the uroflowmetry parameters of elderly men. Voiding in the sitting position was found to be optimal for elderly men, whereas the role of the voiding position in healthy young men could not be determined. More research is needed to further study this issue.
Introduction The first choice of vascular access for hemodialysis in patients with end‐stage renal disease is a distal radiocephalic arteriovenous fistula (AVF). Early failure rates for these AVFs vary from 10% to 53%. The effects of predialysis hypotension on failure of AVFs have been described in the literature. Weather lower blood pressures affect early AVF failure has not been extensively studied. We conducted this study to evaluate the effects of preoperative blood pressures on early AVF failure. Methods Ours was a prospective observational study over a period of 2 years that included 224 patients who underwent distal radiocephalic AVF creation. Only those patients were included whose fistulas were made by surgeons with an experience of greater than five cases. The systolic, diastolic, and mean arterial pressures (MAPs) were recorded preoperatively. Early failure was defined as failure to achieve vascular access from the fistula within first 4 months of its creation. Findings The overall early failure rate was 27.7%. Early failure was more common in females and diabetic patients. The systolic, diastolic, and MAPs were significantly lower in patients with early failure (P < 0.05). In a multivariable adjusted analysis, lower preoperative diastolic and MAPs were predictors for early failure of distal radiocephalic AVF. Discussion Our study shows that patients with early failure of AVFs have lower preoperative blood pressure. A larger study is required to substantiate our findings and define target preoperative blood pressure for AVF creation.
Background: Vaginitis is one of common medical problem in women that often results in frequent medical consultations. Aim was to study the clinico-epidemiological profile and etiopathogenesis of various causes of vaginal discharge among females in age group 18-45 years residing in rural area of Bhojipura district.Methods: This Hospital based cross sectional study was conducted over a period of one year (March 2011 to February 2012) among 150 females aged 18-45 years presenting with the complaint of vaginal discharge. Information on sociodemographic data was obtained with the aid of questionnaires. Samples were obtained with two dry cotton-wool tipped swabs from vaginal fornices and were sending to department of microbiology.Results: The prevalence rate of vaginal discharge was found to be 24.6% among females in reproductive age group attending the outpatient department from rural background. Out of 150 patients who were enrolled for study 86 (57.30%) were diagnosed with non-infective discharge while 64 (42.60%) patients with infective discharge. Bacterial vaginosis was detected in 25 (39.1%), Candida albicans was detected in 23 (35.9%), T. vaginalis in 4 (6.3%) and mixed infections were found in 12 (18.7%). According to vagina flora morphology 85 (56.6%) had normal morphology, 30 (20%) had shift from normal flora and 35 (23.3%) had definitive bacterial vaginosis. About 20.5% females with Candida based etiology were diabetic.Conclusions: Some common reproductive tract infections can be diagnosed and managed at primary level health facilities. This promotes community awareness through behavior change communication which includes safer sex practices, awareness of HIV and appropriate and timely health care seeking behavior.
Background: Pregnancy in jaundice is an important Medical disorder, commonly seen in developing countries like India. The objective of the study was to evaluate the causes leading to jaundice in pregnancy and to analyse the feto-maternal outcome in patients of jaundice in pregnancy.Methods: This was a prospective observational study of antenatal cases with jaundice admitted in the Department of Obstetrics and Gynecology, King Georges Medical University, Lucknow over a period of one year after getting approval of ethical clearance. Total 122 cases were enrolled after informed consent.Results: Total of 122 cases were enrolled, Incidence of jaundice in pregnancy was 1.2%. Majority of patients were of age group 20-25 years 48.4%. About 69.7% presented at gestational age of 29-40 weeks. Most common cause was pre-eclampsia 33.6%, followed by cholestasis 23.75% and hepatitis 17.2%. Amongst hepatitis, most common was hepatitis B in 26.7%. Out of 122 cases, 59.8% delivered while 50.2% were undelivered 52.4% patients improved and were discharged while 47.6% patients expired. Vaginal deliveries were 56.1%, abdominal deliveries were 43.9%, and main reason for maternal mortality was hepatic encephalopathy in 64.6%. Mortality was higher in patients with total bilirubin > 10mg%. Perinatal mortality was 37%.Conclusions: Pregnancy complicated with jaundice carries very poor maternal and fetal outcome. Poor outcome may be attributed to delay in seeking medical advice, lack of awareness, lack of proper antenatal checkups 100% ANC booking can help in reducing fetomaternal morbidity and mortality.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.