Aim: The main focus of the study is to determine the difference between the efficacy of xenogeneic collagen matrix (XCM) versus platelet-rich fibrin (PRF) adjunct to coronally advanced flap to treat the gingival recession. Background: Because of esthetic concerns or root hypersensitivity, typical necessity dictates for buccal gingival recession treatment. This study was planned to evaluate and compare the efficacy of XCM with PRF in the treatment of the recessed gingiva. Materials and Methods: Thirty-four sites with Cairo's RT1 and RT2 gingival recessions were taken, out of which 17 sites received XCM (test) and 17 sites received PRF (control). A periodontal treatment was performed first, followed by a re-evaluation. All clinical measurements, including recession height (RH), recession width (RW), clinical attachment level (CAL), keratinized tissue width, and keratinized tissue thickness, were taken before surgery (baseline) and at a 6-month interval following periodontal surgery. Landry's healing index was also measured at the 1 st and 2 nd weeks after surgery. Results: None of the acquired data implies a significant difference statistically for CAL, RW, RH, thickness, and width of keratinized tissue (WKT) at 6-month interval between both the groups. Comparison of healing at the 1 st and 2 nd week intervals among both the groups showed no statistical significance. No significant difference among both Groups A and B was seen according to the intergroup analysis in terms of periodontal parameters such as CAL ( P = 0.374), RW ( P = 0.542), RH ( P = 0.890), WKT ( P = 0.877) and thickness of keratinized tissue ( P = 0.547), and Landry's healing index ( P = 0.429). Conclusion: In consideration of the patient's comfort and the method's simplicity, it can be concluded that PRF or XCM can be employed as an alternative.
Background: Periodontitis is a multifactorial chronic inflammatory disease. It occurs due to inflammation and destruction of tooth-supporting tissues by subgingival microbiota. Cytokines have major role in the initiation, progression and the host modulation of periodontal disease. Aim: The aim of the study was to evaluate salivary levels of IL-12 in gingivitis and chronic periodontitis participants before and after non-surgical periodontal therapy. Materials and Methods: A total of 56 participants having gingivitis and chronic periodontitis were included in the study. The clinical parameters included plaque index (PI), gingival index (GI), pocket probing depth (PPD) and clinical attachment loss (CAL). The level of IL-12 in salivary fluid was measured by ELISA kit at baseline and at 1 month followed by scaling and root planing. The statistical analysis was performed by using Paired and Unpaired t-tests. Results: After scaling and root planing, all the clinical parameters showed statistically significant improvement in both gingivitis and periodontitis group except plaque index but in comparison, periodontitis group showed more improvement than gingivitis group. IL-12 levels increased in both the patients with gingivitis and periodontitis after scaling and root planing but the intragroup comparison was statistically non significant. On intergroup comparison, increase in the IL-12 level was statistically significant for periodontitis group as compared to the gingivitis group. Conclusion: Nonsurgical therapy resulted in a significant improvement in periodontal indices and a marked increase in IL-12 levels.
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