IntroductionAutism is a set of pervasive heterogeneous neurodevelopmental disorders characterized by early onset of impairment of reciprocal social interactions and communication development along with extremely restricted and repetitive stereotyped behaviors (1). The worldwide prevalence of autism is about 1% (2).There is substantial evidence implicating genetic heritability and environmental factors in addition to oxidative stress, inflammation, and immune dysregulation in the pathogenesis of autism. Although no single coherent explanation has emerged (3), some recent research studies suggested the implication of abnormalities in plasma amino acids in the etiology of autism (4-6).The aim of the present study was to assess the clinical significance of plasma amino acid profile assay in autism using cation-exchange chromatography with ninhydrin postcolumn derivatization.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.