Background: Meningitis is an inflammation and swelling of the membranes that cover the brain and spinal cord. These membranes are called meninges. Meningitis is most often caused by an infection. This disease can be fatal or cause serious lasting side effects. Meningitis is an infection that causes inflammation of the meninges Aim: The study aimed to assess effectiveness of educational instruction of nurses' knowledge regarding meningitis and universal precaution measures at Minia Fever Hospital. Study design: A descriptive cross-sectional research design was utilized in this study. Subject: A convenient sample of 50 nurse were selected from all departments (kidney department and pediatric department, outpatient, inpatient unit for infectious disease as typhoid fever, puerperal sepsis, meningitis and hepatitis A virus), who divided into 14 nurses had bachelor degree, 10 nurses had diploma in nursing and 26 nurses had Technical institute. Setting: This study was carried out at Fever Hospital in Minia city. Tools: Three tools were utilized in this study, The First Tool; was an interviewing structured questionnaire sheet concerned with the socio-demographic characteristics about studied nurse. Second Tool; was concerned with nurses knowledge Assessment questionnaire about meningitis, including of (18) questions. Third Tool; include Knowledge assessment tools regarding universal precaution of meningitis, it consisted of (30) questions. Results The most of study subjects have unsatisfactory level of knowledge about meningitis with mean scores of 9.3±2.7 and most of study subjects have good knowledge about universal precautions regarding meningitis with mean scores of 24.4±6.8. Conclusion: the most of study subjects have unsatisfactory level of knowledge about meningitis and less than fifth have satisfactory level of knowledge about meningitis and the most of study subjects have good knowledge about universal precautions regarding meningitis. Recommendations: Encourage the nurses to participate in training courses held by specialists in meningitis to update their knowledge and increase nurse's knowledge and updated in pediatric unit in the hospital with the current researches and guidelines by taking a training course.
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