regeneration of the primary C0 2 acceptor, phosphoe«o/pyruvate (PEP), from pyruvate and ATP/Pi: Pyruvate + ATP + Pi <-> PEP + AMP + PPiThe reversible, three-step catalytic mechanism is complex and sequentially involves the (i) pyrophosphorylation of an activesite His residue (His-458 in maize PPDK) with the P-and y-phosphates of ATP, forming PPDK-HisPPpT and AMP, (ii) transfer of the y-phosphate to Pi, yielding PPDK-HisPP and PPi, and finally (iii) phosphorylation of pyruvate by PPDK-HisPP, forming PEP and free enzyme [5,6]:
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