This paper deals with the static compression behaviour of concrete-filled double-skin tubular (CFDST) columns with corrugated plates. These sections take advantage of the high strength of their infill concrete as well as the ductility of their steel skins. Static compression tests were performed on CFDST column specimens with inner or outer skins built up from corrugated plates. The steel hollow sections fabricated from corrugated plates exhibited a more stable response under axial compression loading. Hence, implementing them in CFDST columns is expected to enhance the overall behaviour of these columns. These tests reveal how the overall behaviour of CFDST columns is affected by replacing their inner/outer skin with one fabricated from corrugated plates. The corrugated plates have an insignificant effect on the strength of column specimens. However, the ductility and energy absorption capacity of CFDST columns are improved dramatically. A finite element modelling framework was also developed to simulate the response of CFDST columns with corrugated plates and validated against the results of the experiments.
Background and aims: Radiotherapy ranks among the most important procedures in ovarian cancer therapy. However, radioresistance is becoming more prevalent and is one of the main causes of poor clinical outcomes. To overcome this problem, radiosensitizers may be used. The present study aimed to evaluate the radiosensitizing properties of galbanic acid (GBA) on ovarian cancer cells in vitro. Materials and methods: OVCAR-3 cells, an ovarian cancer cell line, were treated with increasing concentrations of GBA (5, 10, 20, and 40 μg/mL) for 24, 48, and 72 h to determine its half-maximal inhibitory concentration (IC50). Cell viability was assessed by alamar Blue assay. The cells treated with 10 μg/mL GBA for 24 h were exposed to increasing doses of radiation (1, 2, and 4 Gy) and the survival fraction was investigated by clonogenic assay. Results: Assessment of cell viability indicated that GBA caused toxicity in a dose-dependent manner. Additionally, GBA pretreatment significantly improved the radiosensitivity of the cells, and survival fraction data indicated synergy between GBA and radiation. Conclusion: Taken together, the current findings highlight GBA as a potent radiosensitizing agent; however, further research is required to determine the molecular mechanisms of the observed effect both in vitro and in vivo. It is also suggested that the radiosensitization effect of GBA on other cell types should be studied in the future.
In order to assess the boundaries of the simultaneous demands on the column members of Special Moment Frames (SMFs), a thorough investigation in the following research were performed on several different archetype frames. Beside the boundaries of the simultaneous seismic demands, the fluctuation of these demands was also analyzed after numerous non-linear dynamic analyses on sample SMFs. These analyses paved the way to establish a representative framework for loading the column members in order to represent the seismic demands expected to be developed on these members. The maximum story drift among all analyses did not exceed 0.06, while a peak axial force more than 30% of their nominal axial yield strength was not captured among all the columns of the sample frames. Chosen archetype columns were loaded under introduced loading framework, and their response compared with the responses of the same columns when the lateral loading is implemented in conjunction with a constant level of axial loading.
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