Raman spectroscopy which is based upon inelastic scattering of photons has a potential to emerge as a noninvasive bedside in vivo or ex vivo molecular diagnostic tool. There is a need to improve the sensitivity and predictability of Raman spectroscopy. We developed a grid matrix-based tissue mapping protocol to acquire cellular-specific spectra that also involved digital microscopy for localizing malignant and lymphocytic cells in sentinel lymph node biopsy sample. Biosignals acquired from specific cellular milieu were subjected to an advanced supervised analytical method, i.e., cross-correlation and peak-to-peak ratio in addition to PCA and PC-LDA. We observed decreased spectral intensity as well as shift in the spectral peaks of amides and lipid bands in the completely metastatic (cancer cells) lymph nodes with high cellular density. Spectral library of normal lymphocytes and metastatic cancer cells created using the cellular specific mapping technique can be utilized to create an automated smart diagnostic tool for bench side screening of sampled lymph nodes. Spectral library of normal lymphocytes and metastatic cancer cells created using the cellular specific mapping technique can be utilized to develop an automated smart diagnostic tool for bench side screening of sampled lymph nodes supported by ongoing global research in developing better technology and signal and big data processing algorithms.
Outstanding Members and Chapters he Chapters and Membership Development (CMD) Department is pleased to announce the winners of the 2015 CMD awards and contests for activities in 2014. It is my great honor to express my sincere congratulations to all of the contest participants, especially the winners. The Chapter contest was characterized by ■ region 10, Vimal Jyothi Engineering college, sB IAs chapter, Kerala section, India chair: Jyothis Joseph Cochair: Sneha Ramakrishnan Advisor: nikhil Valsan K. Continued Performance Outstanding SB Chapter ■ region 8, Budapest university of technology and Economics, SB IEEE Power and Energy society (pEs)/IAs chapter, Hungary section chair 2014: Beáta polgári chair 2015: Ákos Baldauf Advisor: richard cselko.
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