A simple working definition of this term'Gel' is a soft, durable or solid material,containing both solids and liquid parts, where the solid part(gelator) exists as amesh / network of aggregates, viz immobilize part of the liquid,a strong network prevents the liquid from leaking flow, especially by local pressure. The gel is called a hydrogel or Organogel depending on the type liquid component: water in hydrogel and a living solvent in organogels .Organogels have been discovered as a multipurpose tool in pharmaceuticals for topical as well as transdermal delivery of various drugs. They are semisolid classifications consists of apolar phase and a solid phase. Gels are form through the mechanism of entrapment of a polar segment into the three-dimensional networked assembly of solid phase. Apolar phase is inculded as a solvent such as isopropyl palmitate, isopropyl myristate etc.an organogelator such as sorbiatanmonostearte, lecithin etc. are consist by solid phase Organogel, non-crystalline, nonglassythermoreversible (thermoplastic)solid materials and viscoelastic system,can be considered semi-solid an immobilized preparation external apholar phase. Apholar the section closes between spaces of a three-dimensional network a structure built due to physical condition negotiation between collectors compound properties considered as gelators. Generally, these programs are supported in structurant integration molecules .These systems are good transporter for both hydrophilic and lipophilic therapeutic agents. The present review describes a number of important properties of organogel, different types of organogel based on organogelator, method of preparation and various applications in pharmaceuticals.
The demands for fast dissolving tablets have received ever increasing day by day during the last decade. In the present projected study, the effect of natural Super disintegrants was compared with synthetic Super disintegrants and conventional Super disintegrants in the of fast dissolving tablet formulation of Meclofenamate Sodium. Meclofenamate sodium NSAID is used for the treatment of mild to moderate pain in various conditions like (e.g., dental pain, osteoarthritis) and to decrease pain and blood loss during menstrual periods. It is also used for other treatments like reducing pain, swelling, and joint stiffness caused with rheumatoid arthritis. In the present work 9 formulations of FDT (Fast dissolving tablet) of Meclofenamate Sodium were prepared by using Super disintegrants was evaluated and compiles with the official parameters and specifications. Various formulations were prepared using four different super disintegrants namely natural super disintegrant Banana Powder, sodium starch glycolate, crosscarmelose sodium with three concentrations (2%, 4%, 6%) by direct compression method. The blend was evaluated for pre-compression parameters like Angle of repose, bulk density, tapped density, and then tablet evaluated with various post-compression parameters like thickness, drug content, hardness, weight variation, wetting time, friability, disintegration time, dissolution time, drug release study. Formulation F2 showed the lowest disintegration time and in-vitro dissolution studies recorded that formulation F2 showed 98.55% drug release at the end of 3 minutes. The best formulations among these were also found to be stable and optimized formulations were subjected to the stability studies as per ICH guideline.
Digital Image Denoising is one of the most important and difficult techniques in image research. The aim of image Denoising is to improve the visual appearance of an image, or to provide a "better transform representation for another automated image processing. Many images like medical images, satellite images, aerial images and even real life photographs suffer from poor contrast and noise. It is necessary to enhance the contrast and remove the noise to increase image quality. One of the most important stages in medical images detection and analysis is image Denoising techniques which improves the quality of images for human viewing, removing blurring and noise, increasing contrast, etc.
The wireless sensor network technology is an enter constituent for universally acclaimed communication. A wireless sensor network consists of a huge number of sensor nodes. Each sensor node senses environmental circumstances such as temperature, light, force and sends the sensed data to a base station which is an extensive way rancid in universe. Since the sensor nodes are powered by inadequate power batteries, is regulate to lengthen the life time of the network, low energy expenditure is important for sensor nodes. A technique is proposed for optimization of power consumption in wireless sensor network. Here some energy efficient protocols are present, developed from conventional clustering protocol of Federal and distributed clustering protocol. The simulations are performed on omnet++ and which prove that the proposed protocol is better than LEACH and other approaches available.
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