Ophthalmic timolol resembled intravenous timolol in terms of systemic bioavailability, plasma kinetics, and cardiopulmonary effects. Clinicians should pay attention to the high systemic bioavailability of ophthalmic timolol, because intensive systemic beta-blockade can be highly hazardous to aged patients suffering from cardiopulmonary diseases.

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J. 2005. Overcompensation and adaptive plasticity of apical dominance in Erysimum strictum (Brassicaceae) in response to simulated browsing and resource availability. Á/ Oikos 111: 179 Á/191.In the cases where overcompensation has been observed in monocarpic herbs, overcompensation is associated with an apically dominant shoot architecture of intact plants, increased lateral branching following herbivory, and increased reproductive success as a consequence of damage. The compensatory continuum hypothesis expects overcompensation to be more prevalent in resource rich environments compared to poor environments. This is paradoxical since in resource rich conditions the intact plants should branch most vigorously and hence any further increase in branch number should lead to lower seed yield. An explanation could be that apical dominance is rather insensitive to changes in resource availability, and that overcompensation is possible in conditions where plants experience meristem limitation (due to apical dominance) in relation to available resources.We explored the branching patterns and fitness responses of tall wormseed mustard (Erysimum strictum ) to simulated browsing, soil nutrients, and competition in common garden. Competition increased apical dominance and reduced plant fitness whereas fertilization had the reverse effects. Simulated browsing increased lateral branching and had little impact on plant fitness. Fitness overcompensation was observed only among plants grown in competition and in the absence of fertilization Á/ the most resource poor treatment combination in the experiment. The results contradict both with the compensation continuum and the assumption that apical dominance shows no or very little plasticity in relation to growing conditions. Because directional selection gradients on branch number were invariantly positive irrespective of growing conditions, we propose that, in spite of phenotypic plasticity of apical dominance, the plants appear to be meristem rather than resource limited, and that meristem limitation is strongest in conditions where intact plants produce fewest lateral branches. Our results deviate from the compensation continuum because resource availability affected compensation ability more strongly through phenotypic plasticity of shoot architecture rather than via changes in resource availability per se.

MMP-8 concentration and activation degree in tear fluid are increased in OcR, probably reflecting increased inflammatory activity. Doxycycline effectively reduces these pathologically excessive levels and activation of MMP-8, and relieves patients' subjective symptoms.

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The paper examines the impacts of financial development on sectoral carbon emissions (CO) for environmental quality in Malaysia. Since the financial sector is considered as one of the sectors that will contribute to Malaysian economy to become a developed country by 2020, we utilize a cointegration method to investigate how financial development affects sectoral CO emissions. The long-run results reveal that financial development increases CO emissions from the transportation and oil and gas sector and reduces CO emissions from manufacturing and construction sectors. However, the elasticity of financial development is not significant in explaining CO emissions from the agricultural sector. The results for short-run elasticities were also consistent with the long-run results. We conclude that generally, financial development increases CO emissions and reduces environmental quality in Malaysia.

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The influence of seasonally frozen ground (SFG) on water, energy, and solute fluxes is important in cold climate regions. The hydrological role of permafrost is now being actively researched, but the influence of SFG has received less attention. Intuitively, SFG restricts (snowmelt) infiltration, thereby enhancing surface runoff and decreasing soil water replenishment and groundwater recharge. However, the reported hydrological effects of SFG remain contradictory and appear to be highly site- and event-specific. There is a clear knowledge gap concerning under what physiographical and climate conditions SFG is more likely to influence hydrological fluxes. We addressed this knowledge gap by systematically reviewing published work examining the role of SFG in hydrological partitioning. We collected data on environmental variables influencing the SFG regime across different climates, land covers, and measurement scales, along with the main conclusion about the SFG influence on the studied hydrological flux. The compiled dataset allowed us to draw conclusions that extended beyond individual site investigations. Our key findings were: (a) an obvious hydrological influence of SFG at small-scale, but a more variable hydrological response with increasing scale of measurement, and (b) indication that cold climate with deep snow and forest land cover may be related to reduced importance of SFG in hydrological partitioning. It is thus increasingly important to understand the hydrological repercussions of SFG in a warming climate, where permafrost is transitioning to seasonally frozen conditions.