Abstract. Alrubaie I, Salim AT, Majeed MM, Radhi AJ. 2022. Synthesis of novel polymer quaternary ammonium salt derived from glucose as a phase transfer catalyst. Nusantara Bioscience 14: 25-33. Some new polymer containing quaternary ammonium salts based-carbohydrate starting from methyl-4,6-O-benzylidene-glucopyranoside have been prepared. The ammonium groups are connected to the glucose structure in various positions (2 and 3). Our synthesis used methyl-4,6-O-benzylidene-a-D-glucopyranoside through nucleophilic reagents to produce the main intermediates. The monomer glucose- quaternary ammonium salts are immobilized on the polyvinyl azide to give the final structure of the Polymer-Supported quaternary ammonium salts. In certain new kinds of phase transfer catalysts, the effectiveness of the polymer glucose-quaternary ammonium salts was tested in the Williamson etherification. The ether synthesis is a typical example of using a phase transfer catalyst. The reactions were performed in a liquid-liquid two-phase system, applying a mixture of toluene and 50% solution of aqueous sodium hydroxide in the presence of a 20 mg/mmol catalyst (compound 9). Compared to other derivatives, the reaction of 4-nitrophenol with dibromoethylene gives the highest yields. On the other hand, compound 9 with the C16 chain gives high activity in the phase transfer catalyst.
Abstract. Barrak MH, AL-Rufaie MM, Motaweq ZY. 2021. Thymol quantitative analysis in medicinal formulation types through employing nano-technology and antimicrobial activity in some pathogenic bacterial isolates. Nusantara Bioscience 13: 129-137. This study included a method for estimating thymol (THY) in its pure state and in some of its pharmaceutical preparations that were quick, easy, and sensitive, This method is based on nanoparticles that have been modified by oxidation and reduction reactions, In a sodium hydroxide base medium, with polyvinylpyrrolidone as a stabilizer. The thymol drug works as a reducing agent to dilute the ore mineral salt from silver nitrate (Ag+) to silver nanoparticles; the oxidation-reduction reaction product for thymol has the highest absorption at 410 nm. The calibration curve was calculated, and the following information was determined, indicating that the Beer-Lambert Law was followed within the focus range of 0.25 to 50 parts per million. Sandal's sensitivity was 0.052 ?g/cm2, his molar absorptivity was 2.2883 x 103 L / mol.cm, his standard deviation rate was 0.402%, and his correlation coefficient was 0.9989. The biological effect on a number of Gram-negative and Gram-positive bacteria was studied, and the findings showed that the samples prepared were effective against these bacteria.
A new sulbatamol sulphate SBS membrane electrode was prepared that utilizing for its determination ; depend on the forming of the association complex ion of sulbatamol sulphate by the phosphotungstate counter anion deposed in poly vinyl chloride PVC polymer, by use a (Di-n- Octyl Phenyl Phthalate)(Dopp) as the plastizier substance, in membrane.The features properties as well as the behavior of it .The new electrode have been elaborated. The concentrations of medicine by utillizing This sensor show a fast, stable, near-Nernstian response in the range (1x10-1-1x10-6) mol/ L were determined with correlation coefficient of about (r = 0.9991) and with of a relative standard about 0.416 additionally deviation relative standard error of 1.710 %.pot The nernast linearity slop was founded and it is equal to 28.9 mV/decade and the detection limit was 4.1 x 10-6 mol/ L.The electrode selectivity coefficient Ki,j was calculated, in the existence of several interferences cations with confirmed medicine solutions. It was found the pH range response is in the range of (3 -7), with the response time of (30 – 116) sec. for various concentrations at room temperture , the lifetime for electrode was found to be more than 21 days. The electrode was successfully used for potentiometric limitation of sulbatamol sulphate in several pharmaceutical drugs by using direct potentiometry.
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