Background: Epidemiologic findings revealed approximately one-third of patients with breast cancer develop brain metastases. Recent research has found that schizophrenia patients who take antipsychotic medications on a long-term basis have a decreased risk of cancers than normal individuals. This serendipitous anticancer action of antipsychotic medications is now being investigated by many studies. The ability of these drugs to penetrate the blood–brain barrier may target brain metastases. We investigated antiproliferative activity of antipsychotic drug. The present study aimed to determine the antiproliferative effects of olanzapine against MCF-7 cells and also to examine its molecular interactions with survivin. Methods: The antiproliferative effects of olanzapine were demonstrated using MTT assay and molecular interactions were analyzed using AutoDock Vina ver4.0 between olanzapine (PubChem CID − 135398745) and survivin (PDB ID − 1E31). These molecular interactions were also compared with tamoxifen (PubChem CID: 2733526). Results: We found that olanzapine has extensive antiproliferative effects against MCF-7 human breast cancer cells, with an IC50 of 10.9 g/mL. We also discovered that olanzapine had possible interactions with the survivin protein at Lys15, Phe86, and Val89 amino acid residues, which could be related to effects of olanzapine on MCF-7 cell viability. Conclusion: Our research establishes that olanzapine has promising anticancer properties against breast tumors, with prospective application to target brain metastases in patients with breast cancer.
Background: Advanced technologies such as a smartphone, laptop, tablet, and iPad allow web browsing and use of online applications (Apps). It is a novel thought to integrate medical educational Apps in academic curriculum. They facilitate a quick access to evidence-based information. Usage of Educational Apps is constantly rising in developing countries like India. Hence, it is rationale to understand the use of Educational applications as an academic tool among medical students from a developing country context. Aims and Objectives: The aims and objectives of the study are to assess the utility of Educational applications in Medical Education and its advantages and disadvantages, among undergraduate Medical students. Materials and Methods: The study was designed as a cross-sectional survey to assess emerging patterns of educational applications use by medical undergraduate students. A structured Google Form online-based questionnaire was utilized for our study as a method of data collection. Results: In our study, we found that above 60% of 205 electronic device users were using their device for medical education. There was significant increase in the use of electronic device in medical education for online lectures, notes taking in our study. Study participants had an upstanding opinion (P = 0.79) toward advantages of electronic devices which were insignificant in the study. The responses by participants of various domains which include utility, opinion, perspectives, and limitations in addition to their correlation was analyzed. Conclusion: The lessons learned from this study are majority of the students use educational applications mainly for learning and communication purpose. With increasing use of electronic devices by students, it is rationale to consider these applications in the learning environment and incorporate in the medical curriculum in the near future.
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