Arylidene analogs are well proven for biological activities. FCY-302, a novel small molecule belonging to this class, was screened for its biological efficacy in leukemia and myeloma cells. FCY-302 selectively inhibited proliferation of cancer cells with GI50 values of 395.2
nM, 514.6 Nm, and 642.4 nM in HL-60, Jurkat, and RPMI-8226 cells, respectively. The compound also increased sub-G0 peak in the cancer cell cycle and favored apoptosis determined by annexin V assay. The compound decreased the antiapoptotic Bcl-2 levels and increased proapoptotic
Bax proteins in leukemia and myeloma cell lines. FCY-302 attenuated the mitochondrial membrane-bound Na+/K+ ATPase, Ca2+ ATPase, and Mg2+ ATPase enzyme activities and significantly decreased activities of antioxidant enzymes like SOD, CAT, GR,
and GST in all the three cancer cells tested. Our findings suggest that FCY-302 inhibits the proliferation of leukemia and myeloma cancer cells by altering key mitochondrial and antioxidant enzymes, eventually driving them to apoptosis. These results drive focus on FCY-302 and its analogs
to be developed as potential small molecules with bioactivities against cancer.
Abstract:A compact monopole ultra-wideband (UWB) antenna with WiMAX band rejection is proposed. The proposed antenna is optimized to be 12 × 18 mm 2 in size and cover the frequency band from 3.1 to 11 GHz with rejection of the WiMAX band. The antenna is simulated, fabricated, and tested; the measured results show good agreement with the simulation results. The proposed antenna presents satisfactory radiation characteristics.
Embedded Systems-on-Chips are becoming more complex and multi-functional; consist of tens or hundreds of integrated IPs supporting one or several applications. For such systems, Network-on-Chip (NoC) is proposed to overcome the communication challenges and bandwidth bottlenecks. In this work, we propose the use of Network Coding (NC) for NoCbased SoC to improve performance in terms of latency and power consumption. Network coding is a technique allows nodes to combine arriving packets into encoded packets instead of simply forwarding them. NC aims to optimize data flow leading to improve network throughput and reliability. This paper discusses the feasibility of NC for multicast communication in NoC and presents a set of algorithms to select intermediate nodes in order to apply NC; also introduces a heuristic to rapidly identify the applicability of NC according to the relative positions of sources and destinations nodes. Moreover we evaluate NC potential for multicast communication over various NoC sizes under different evaluation parameters (number of hops, steps and live packets). It was possible to achieve performance improvement by reducing the total number of hops by 24% and total number of live packets by 35%. These results demonstrate the potential of NC to enhance NoC performance.
This paper discusses the design of 3D monolithic integrated inductors. The proposed 3D radio frequency (RF) integrated inductors have high inductance (L) values with an enhanced quality factors (Q). A new proposed method for 3D integrated inductors design is presented. A wide range of inductances and quality factor values can be realized. The proposed 3D inductors were designed in TSMC 0.18 μm technology and simulated using momentum.Keywords-3D monolithic integrated inductor; inductance(L) and quality factor (Q)
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