Background and aims: Elders at an increased risk of getting the novel COVID-19 infection. Materials and Methods: We analyzed the clinical presentations, laboratory and radiological investigations, and the patient's outcome in fifty seniors aged 60 years and more who were hospitalized due to COVID-19 infection in the period from December 2020 till March 2021. Results: The mean age was 68.2 ± 5.9 years (60% males and 40% females), 70% with comorbidities. Our patients exhibited a variety of clinical manifestations (constitutional, respiratory, gastrointestinal, and atypical) and hematological presentations with variable percentages. The mean period of hospital stay was15.05 days with 60% of the patients cured and 40% died (60% males, 40% females). The causes of death were septic shock (81.8%), ARDS (36.3%), AKI (18.2%), DIC (13.6), and encephalitis (9.1%). Using multivariant regression analysis and Roc curve analysis; levels of D-dimer >901ng/ml, interleukin-6 >13.5pg/ml, and >30% lung involvement were independent predictors of mortality after adjustment of other predictors. Conclusion: Elderly patients are vulnerable to complications caused by SARS Cov-2 infection especially in the setting of multiple comorbidities. Unexpectedly, gastrointestinal manifestations were associated with mortality in seniors along with low oxygen saturation, and wheezy chest. After multivariant regression analysis only D-dimer, interleukin-6, and the degree of lung involvement in CT were independent predictors of mortality in seniors after adjustment of other predictors.
The aim of the present study is to through lights on the biochemical relations between H. pylori infection and the changes in serum Ammonia, Gastrin, Leptin, Amylase, Lipid profile, Iron, Total Iron Binding Capacity, Transferrin, Haptoglobin and Vitamin B12. 90-helicobacter pylori infected patients, and 20-clinically healthy subjects used as control all ages ranged between 25 to over 65 years are applied in the experiment. The result of the present study showed the association between serum Ammonia and Amylase, Gastrin and Leptin levels, in addition to serum lipid profile including (Total cholesterol, Triacylglycerol (TG), Low density lipoprotein-cholesterol (LDL-C) and High density lipoprotein-cholesterol (HDL-C), Iron status (Iron, Ferritin, Total Iron Binding capacity (TIBC) and Transferrin) in addition to Vitamin B12 and haptoglobin with helicobacter pylori infection. These parameters may all be regarded as predictors or risk factors for Gastritis, anemia, peptic ulcer, Gastric cancer and Coronary heart diseases in elderly patients. The findings of the present study suggest that, helicobacter pylori infection are primary interacting mediators in the anemia and different diseases of the stomach.
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