One of the rare dermatological illnesses that might cause a medical emergency is SJS/TEN. SJS/TEN trigger an aggressive immune reaction to destroy the epithelium of the skin and mucous membranes. They are lifethreatening mucocutaneous responses with death rates as high as 30% and a wide range of acute and chronic morbidities. Therefore, early detection and adequate and early treatment can save the patient's life. To review the evaluation of SJS/TEN clinical manifestations and the different aspects of the management. PubMed database search engine was the preferred method for data selection, and the following keys were used in the mesh (("Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis"[Mesh] ) AND ("evaluation"[Mesh]) OR ("management"[Mesh])). While there is no test or set of criteria that can determine whether or not an individual has Steven-Johnson syndrome or Toxic epidermal Necrolysis, a skin biopsy can assist in determining other illnesses that have clinical manifestations.Provided there is no effective approach to treat SJS/TEN, presently the best approach is to have a great doubt for the syndrome, early clinical diagnosis, immediate discontinuation of suspected causing substance, supportive therapy, and close monitoring for and treatment of high morbidity complications like infection and ophthalmologic sequelae. Moreover, pain control is crucial to retain a sense of the mental and physical wellbeing of the patients.