Covid-19 is a genus of enveloped, positive-sense, single-stranded RNA viruses with a high degree of genetic diversity. They induce a variety of disorders affecting the respiratory, gastrointestinal, hepatic, and nervous systems in humans and animals, with different manifestation and severity. Several risk variables, including older age, male gender, type 2 diabetes mellitus, hypertension, coronary artery disease, and obesity (a higher body mass index (BMI)), are known to predict a worse course of covd-19 infection. Obesity is the result of the accumulation of an excessive amount of fat in the body and the condition arises from an imbalance between the amount of energy stored by increased food intake and the amount of energy expended as physical activity. The aims of study evaluate the effect of covid-19 on cytokines levels in obese patients. As well as, study the association of adiponectin gene polymorphism to the risk of infection with covid-19 in obese patients.
Objective: Breast cancer is the most diagnosed cancer in women, which leads to death in a lot of women with breast cancer. The major risk factors associated with breast cancer risk related to family history, age, clinical history, lifestyle factors, long-period hormonal exposure, and single nucleotide polymorphisms in many genes showed possible links with breast cancer incidence risk in different people populations. Our study aimed to figure out the correlation between smoking, lodging and family history, and other factors with the risk of breast cancer.Methods: Blood sample from female patients with breast cancer and healthy individuals were collected and subjected to tetra-amplification refractory mutation system-polymerase chain reaction (T-ARMS-PCR) technique for −607 C/A mutation of an interleukin (IL-18) gene and SPSS 18 software analyzed the results statically.
Results:Results showed no association between lodging and smoking with risk of breast cancer, (p>0.05), while the association between the risk and family history were obvious (p<0.05).
Conclusion:The results obtained by T-ARMS-PCR technique did not show the association between −607 C/An alternation of IL-18 gene and breast cancer (p>0.05) in the individuals examined in our study.
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