Background: Today, it is well accepted that the quantitative measurement of anticancer drugs in human biological samples requires the development and validation of efficient bioanalytical methods. This study attempts to provide a high-capacity and thermo-sensitive nano-adsorbent for bicalutamide extraction from human biological fluids.
Main Methods and Major Results:In this study, five generations of thermo-sensitive dendrimers were synthesized onto the surface of WS 2 nano-sheets. After drug-loading process from body fluids, the near-infrared (NIR) light (at 808 nm) was applied and light-to-heat conversion by the WS 2 nano-sheets led to shrinkage in polymer chains, resulting the release of the entrapped drug. Finally, the extracted drug was analyzed via HPLC-UV system (at 270 nm). The final nano-adsorbent was described via FE-SEM, XRD, FT-IR, and TGA techniques. The adsorption isotherm data were well fitted by Langmuier isotherm model (R 2 = 0.9978). The mean recoveries for spiking bicalutamide at three different concentrations in plasma and urine samples were 92.12% and 94.54% under the NIR light irradiation.
Conclusions and Implications:We have developed a smart strategy to analyze bicalutamide in biological samples using near-infrared light irradiation in a controlled manner. All the results indicate the promising application of the proposed method for the extraction and determination of bicalutamide.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.