Angiomyolipoma (AML) is the most common benign renal mesenchymal neoplasm. This is a report of a 36-year-old female patient with AML with the involvement of the inferior vena cava (IVC) who was admitted to our hospital. The patient complained of mild right flank pain. CT scan results showed a hypo-dense mass with 47×72 mm dimensions at the right kidney›s lower pole suggesting renal AML. In MRI with contrast, venous thrombosis was detected in the right renal vein and IVC. Right radical nephrectomy and IVC thrombectomy were successfully conducted. Renal AML was confirmed by pathological findings, and the presence of tumor thrombosis was approved in the right renal vein and IVC. Although AML is generally benign and vascular invasion is a rare finding in this condition, imaging studies (including CT scans) should always be considered to determine the extent of vascular involvement and choose an appropriate therapeutic plan, including nephrectomy and thrombectomy in case of vascular involvement. Despite its benign nature, it should be considered that AML can invade venous structures in the kidneys. Early imaging studies and therapeutic interventions are necessary for obtaining the best outcome.
OBJECTIVE: To compare the results of stem cell therapy with mini-sling for women’s stress urinary incontinence. METHODS: This study was parallel groups noninferiority randomized clinical trial. Patients with pure stress urinary incontinence who did not improve after three months of conservative and medical therapy were included. Patients were divided into two groups of mini-sling insertion or peri-urethral injection of the autologous mucosa stem cell with simple equal randomization. Standard Incontinence Impact Questionnaire (IIQ) questionnaire, patient satisfaction as well as objective Marshal Test as primary outcome were compared. RESULTS: From October 2016 to March 2018, 30 patients (mean age of 52 years) were randomly divided equally in two groups. Finally, a negative Marshal test was observed in 73% of the stem cell group vs 80% in the Mini-sling group (p=0.6). The mean decrease in the IIQ results was 12 points in the stem cell group vs 25 points in the Mini-sling group (p=0.05). Favorable results at 6 m and 26 m follow-up were 40% vs 80% (p=0.06) and 53% vs 60% (p=0.7) in stem cell and Mini-sling group respectively. Patients in the Mini-sling group experienced higher rate of dyspareunia. Intervention time and hospital stay were 6.46±1.24 minutes in vs 19.40±4.30 minutes (P=0.001) and 4.33±1.23 vs 9.20±3.16 hours (P=0.001) in stem cell and Mini-Sling groups respectively. CONCLUSION: Results of the periurethral injection of the autologous adult mucosa-derived stem cells are not inferior to the less invasive mini-Sling procedure; while, stem cell group showed shorter intervention time and hospital stay as well as fewer complications.
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