Objective: To observe the protective effect of zingiber officinale against radio frequency (RF) radiation-induced oxidative stress on rat brain due to 3G mobile phone. Study Design: Prospective Experimental study. Setting: Department of Anatomy, BMSI, JPMC, Karachi. Period: January to March 2018. Material & Methods: Twenty four healthy, adult, Albino rats, 3-4 months of age, weighing 150-300 gm were acquired. They were sorted into four groups. Group A was marked as control, Group B was exposed to 3G mobile phone 2100MHz radiation 24 hours daily, Group C was exposed to same dose of radiation as group B along with zingiber officinale 250mg/kg/day orally, and Group D was given same dose of zingiber officinale as in group C. The rats were euthanized at end of study period after recording their final weight. Brain of rats was removed and weighed. It was processed for haematoxylin and eosin stain to observe general morphology of cerebellum. Results: The data displayed an insignificant increase in final body weight and absolute brain weight in group B animals as compared to control, whereas an insignificant increase and insignificant decrease was observed in body weight and absolute weight of brain when group C was compared with group B respectively. Microscopic examination of cerebellum in H & E stained sections revealed distortion of cellular architecture in group B as compared to control. Tissue sections from group C demonstrated significant restoration of cerebellar architecture. Results of group D were similar to control. Conclusion: Cell phones emit radiation causing damage to brain, especially cerebellum, however, concurrent use of ginger significantly ameliorates this damaging effect.
Background:Use of dietary supplements to treat illnesses has increasedtremendously in recentyears.Adrenal gland is one ofthemost commonly damaged endocrine gland in the body, not only by chemical or radiation injuries, but also as a result of differenttypes of stress.Search is underway for use ofnatural foods for protection of adrenal gland from different types ofinsults.Objective: To determine the protective effects of L-arginine on streptozotocin (STZ)-induced adrenal gland injury in albino rats,andto compare its efficacy to insulin.Material and Methods: This prospective experimental study was done at BMSI, JPMC, Karachi. Forty male, healthy albino rats,90-120 days old were segregated into 4 groups. Group A was marked as control, group B was administered STZ, group C and Dwere treated with STZ along with insulin and L-arginine respectively. At the end of study period, i.e., 6 weeks, animals weresacrificed under ether anaesthesia. Tissue from the left adrenal gland was processed for frozen sectioning to observe fat content ofthe adrenal cortex by applying OilRed O stain.Results: Oil Red-0 stained frozen sections revealed closely aggregated fat globules in adrenal cortex of STZ treated group B ascompared to control. Moderate betterment was seen in group C and in group D Oil Red O stained frozen sections as compared toSTZ treated group B.Conclusion: The results ofthe study demonstrated adrenal cortex injury by STZ which ameliorated with concomitant use of insulinandL-arginine. The protection was more pronounced with L-arginine as comparedto insulin.Keywords:STZ, adrenal gland,insulin,L-arginine
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