Vanillin plays an important role in flavouring and as aroma agent. Vanillin has been used as a chemicalintermediate in pharmaceutical and chemical syntheses. Schiff base products have been proved to posesbeneficial biological effect towards health. Fourteen vanillin derivatives were synthesized via Schiff basereaction using p-vanillin as the starting material reacted with 2-aminobenzenethiol, furan-2-carbohydrazide, 2-hydrazinylpyridine, 4-hydroxybenzohydrazide, acetohydrazide, benzohydrazide, (diphenylmethylidene)hydrazine, pyridine-4-carbohydrazide, benzene-1,2-diamine, phenylhydrazine, 2-hydroxybenzohydrazide, 1,3-benzothiazol-2-amine, 1-cyclohexylthiourea respectively. All of the compounds were characterized by elementalanalysis, FTIR and 1H NMR.
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