In a study of 307 white patients who underwent coronary angiography, the relationship of coronary artery disease (CAD) to plasma levels of lipoprotein Lp(a) No. 4, 758-765, 1986. THE ASSOCIATION between coronary artery disease and a plasma lipoprotein migrating on agarose gel or cellulose acetate electrophoresis as a distinct pre-beta, band was reported independently in 1972-1973 from several laboratories.'-3 The activity of the pre-beta, lipoprotein4 was soon discovered to be identical to Lp(a) plasma antigenic activity, discovered by Berg in 1963,5 and results of qualitative assays for Lp(a) likewise were associated with various manifestations of coronary artery disease.4 6 7 Studies using quantitative assays of plasma Lp(a) have tended to confirm an association with coronary artery disease, but thus far statistically significant associations have been reported from these studies only in the context of retrospective subgroup analysis8' 9 or dichotomization of Lp(a) lev-
Introduction: Visfatin is an adipocytokine secreted from adipose tissue and can lead to the occurrence of diabetes. Omega-3 can decrease lipid profile and prevent insulin resistance. In the present study, the effect of Omega-3 on the serum visfatin concentration was compared with placebo. Material and Methods: A total of 71 women with type II diabetes were randomly assigned to a group that administered Omega-3 capsules or control group. First, the study subjects filled in a questionnaire including age, height, weight, waist circumference, and hip circumference. In addition, blood samples were taken to do the blood tests. In the second step, the intervention was done for 8 weeks and then data on the aforementioned variables were collected. In the blood samples visfatin and lipid profiles (LDL: low density lipoprotein, HDL: high density lipoprotein, TG: triglyceride and cholesterol), glucose, and HbA1c were measured. Results: There was no significant difference in serum visfatin level between groups before the intervention (p=0.14). However, after the intervention, the mean serum visfatin level in the Omega-3 group was significantly (P<0.001) higher. In addition, the mean differences before and after the serum visfatin level showed a significant difference in both groups (P<0.001). Conclusion: The use of omega-3 can increase visfatin level and also improve the effect of insulin in patients with type 2 diabetes. According to the similar effects of insulin and visfatin, the use of Omega-3 by diabetic patients is recommended. Also, further studies are recommended to be conducted on his subject to confirm the results of this study.
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