The current study aimed to prepare a topical gel containing solid lipid nanoparticles (SLNs) encapsulating fluoxetine for diabetic wound healing effects. Fluoxetine (FX) was loaded into SLNs by employing an emulsion solvent evaporation technique using stearic acid as a lipid, and soya lecithin as a surfactant. SLNs were then evaluated for particle size, polydispersity index (PDI), zeta potential (ZP), percent entrapment efficiency (%EE), percent drug loading (%DL), and in vitro drug release. The optimized SLN (FS3) composed of FX (100 mg), SA (150 mg), and SA (100 mg) displayed mean particle size (467.3 ± 2.2nm), PDI (0.435 ± 0.02), ZP (−32.2 ± 4.47mV), EE (95.8 ± 3.38%), and DL (16.4 ± 2.4%). FTIR and DSC studies denote drug-polymer compatibility and the amorphous nature of FX in the SLNs. The drug release at 24 h was found to be (98.89 ± 2.57%) which followed the fickian diffusion mechanism. SLN (FS3) was further loaded into carbopol gel and tested for pH, spreadability, and extrudability of pharmaceutical parameters. In-vitro release of FX from the SLN gel and plain gel was compared, diabetic wound healing gel (DWH) showed sustained drug delivery. An in vivo study was also performed for DWH gel in streptozotocin-induced diabetic rats. Histopathological examination exhibited DWH gel-treated wounds have increased hydroxyproline, cellular proliferation, a rise in the number of blood vessels, and the level of collagen synthesis. Thus, DWH gel-loaded SLN encapsulated with FX could be a potential carrier for the effective treatment and management of diabetic wounds.
A bstract Aim To assess and analyze the resin-bonded dentin in terms of shear bond strength after using deproteinizing agents 5% sodium hypochlorite, 10% sodium hypochlorite, and bromelain. Materials and methods Overall 140 permanent and intact human premolars were split into four groups, three experimental groups and one control group. In all four groups, the occlusal surface of the teeth was wet ground to expose superficial dentin. In group I, teeth were etched and deproteinized with 5% sodium hypochlorite. In group II, teeth were etched and deproteinized with 10% sodium hypochlorite. In group III, teeth were etched and bromelain was used to deproteinize. In group IV, teeth were etched and no deproteinization was being performed and simultaneous fulfillment of the resin composite and later inserted into the plastic tube and polymerized with light. Samples were stored at 37°C for 24 hours and the later samples were transferred to the universal testing machines to shear bond strength analysis at a speed of 0.5 mm/minute. Results The outcome of the bond strength was significantly influenced by the application of bromelain enzymes. A remarkable difference was observed between the shear bond strength of sodium hypochlorite (5 and 10%) and in the bromelain enzyme-treated group. Group III showed better results than group I and group II. Conclusion This study concluded that bromelain shear has the maximum value for shear bond strength. Bond strength improved because of removal of unsupported collagen fiber with bromelain enzyme after acid etching. Clinical significance Natural pineapple enzyme, i.e., bromelain improves bond strength by removal of unsupported collagen fiber. Hence, it is completely safe to use. How to cite this article Khan R, Sharma N, Garg Y, et al. Comparison of Different Dentin Deproteinizing Agents on the Shear Bond Strength of Resin-bonded Dentin. Int J Clin Pediatr Dent 2020;13(S-1):S69–S77.
Harmonic scalpel is popular for use in a variety of surgical procedures including thyroid surgery. Proposed advantages of the harmonic scalpel include less lateral thermal tissue damage with no electrical energy transferred to the patient, no neuromuscular stimulation, less smoke formation as compared with electrocautery. Objectives: Our aim was to compare outcomes following thyroid surgery in terms of operative time, postoperative pain, drainage volume, recurrent laryngeal nerve and parathyroid gland injury with the use of the Harmonic Scalpel compared to conventional methods of hemostasis. Study Design: Randomized control trial. Setting: Surgical Department Lahore General Hospital. Period: Twelve Months June 2016 to June 2017. Material & Methods: 60 patients, 30 in each group. Patients were randomized in each group by balloting method. Operative time, postoperative pain and drainage volume was assessed during hospital stay. Recurrent laryngeal nerve and parathyroid gland injury was assessed during hospital stay and follow-up. Results: There was no significant difference in development of hoarseness of voice in both groups, p-value > 0.05. The mean operative time for group A was 69.47 ± 15.44 minutes and for group B it was 54.93 ± 11.56 minutes, p-value <0.05. The overall blood loss in group-A and group-B was 118.73 ± 50.72 ml and 44.60±10.70 ml, p-value<0.05. The mean post-op pain observed at 2nd day for group B was 2.93 ±3.57 and for group A it was 3.57±0.77, p-value < 0.05. Conclusion: Use of Harmonic Scalpel has better results in thyroid surgery in terms of less operative time, less postoperative pain, less drainage volume, while no RLN & parathyroid injury detected in either group.
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