We have recently developed a one-pot
process for simultaneous extraction
and chemical modification (SECheM) on Cienfuegosia digitata, a Mauritanian Malvaceae called locally “Izide”.
On the basis of this innovative methodology that consisted of using
ground plant roots as starting material in gossypol Schiff base semisynthesis,
we now report how this concept can be used to access enantiomerically
pure Schiff base atropisomer derivatives of gossypol in only two steps.
This study has been envisioned since enantiomerically pure Schiff
base atropisomer derivatives of gossypol are generally more potent
biologically when compared to racemic gossypol Schiff bases.
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