The Issaran field, a heavy-oil reservoir with reserves of approximately 500 MM bbl of oil, was discovered in 1981. The producing horizons were carbonate formations of Miocene age occurring at an average depth of 2,200 ft. The oil being produced on artificial lift was of 9° to 12° API in a viscosity range of 3,000 to 5,000 cp. Before mid-1999, nine wells had been drilled in the field with a cumulative production of about 450 BOPD. This field did not command high priority because of its low productivity and the low prices that heavy crude attracts. However, with the oil price increases in 1999 and 2000, the Egyptian government made a concerted effort toward developing this field. New and applied technology provided considerable returns within 1 year of new investments. The field has been producing as much as 1,800 BOPD (a four-fold increase), from five new wells drilled in the area. Plans were made for thermal recovery in the form of steam stimulation for this heavy-oil reservoir, but first, it was necessary to produce under "cold production." Several industry publications1–3 have addressed cold production, predominantly pertaining to sandstone reservoirs. This paper highlights the experiences, challenges, and practical solutions in optimizing production from a fractured, carbonate reservoir. Several leading-edge technologies and optimization techniques that are effective in less-challenging reservoirs have contributed tremendously to enhancing production from this heavy-oil reservoir. The path to success began with the definition of the reservoir-flow mechanism, optimized perforating schemes, ehnanced carbonate stimulation, and improved completion designs. Introduction Field research1 reveals that most heavy-oil production comes from unconsolidated sands originating from fluvial-deltaic deposition. The successful mode of cold production in such wells has been to produce formation sand along with the oil. The use of well-completion designs that allow such recovery is known as sand management. Rate increases of up to 20 times the sand-free oil-production rate (with no sand control) have been reported.4 Several other nonthermal recovery mechanisms for increasing productivity have been identified, such as foamy oil and horizontal well completions (possible variations into multilateral completions) and hydraulic fracturing. In contrast to fluvial-deltaic sandstones, carbonate reservoirs are generally products of a much more serene depositional environment where processes such as cementation, compaction, and recrystallization of the rock resultin a tight and more rigid matrix. In such reservoirs, sand management techniques are not applicable. However, diagenesis in carbonates can sometimes open conduits to flow in the form of fractures or vugs. The task then becomes to identify such fractures and capitalize on their possible contribution to flow. Background The Issaran field was developed initially with the drilling of eight wells between 1981 and 1987. The Issaran oilfield is a major accumulation in terms of oil in place. It is estimated to have approximately 500 MM STB. The field is located 180 miles southeast of Cairo, and 2 miles inland of the western shore of the Gulf of Suez (Fig. 1, Page 8). The Issaran field is of the Miocene age. The field primarily consists of three oil-bearing reservoirs ranging in depth from 1,000 to 2,000 ft. These are the Upper and Lower Dolomite and the Nukhul formations (Fig. 2, Page 9). More recently, the Nukhul formation was further subdivided into the Gharandal formation. The references made to Nukhul in this paper also include the Gharandal formation, unless otherwise specified.
INTRODUCTION: Bone defect above critical size does not heal completely by itself and thus represents major clinical challenge to reconstructive surgery. Tissue engineering is a new approach for the repair of osseous defects. β tricalcium phosphate (β-TCP) loaded with autogenous bone marrow derived mesenchymal stem cells (BMSCs) is suggested to have a promising osteogenic characteristics that support its potential in tissue engineering to repair bone defects. OBJECTIVES: was to evaluate the efficacy of autogenous (BMSCs) by its transplantation into local defects using (β-TCP) as a carrier. MATERIALS AND METHODS: Ten male Mongrel dogs weighing 25 Kg were used in this study. Right and critical size bone defects (CSDs) were performed intraorally at the mandibular premolar area by the aid of trephine bur, of 6mm outer diameter and 5mm inner diameter. Right side bone defects (Experimental) were filled with mixture of (β-TCP) and (BMSCs) which was taken from bone marrow aspirate concentrates (BMACs) from the same animal. Meanwhile, the left side bone defects (control) were left empty for healing spontaneously. The effect of (BMSCs) was assessed histologically as well as histomorphometrically after 6 weeks. RESULTS Greater amount of bone formation was noticed in (CSDs) filled with (β-TCP) and (BMSCs). The amounts of new bone formed in the defects filled with (β-TCP) and (BMSCs) were significantly greater than those formed within the defects that were left empty. CONCLUSIONS: Autogenous (BMSCs) has excellent osteogenic characteristics and can be added to bone grafts following surgical and periodontal surgeries to enhance bone regenerative capacity.
The aim of the present study was to investigate the possible association between incidence and severity of ankylosing spondylitis (AS) in a cohort of Egyptians and Interleukin-23Receptor (IL23R) genesingle nucleotide polymorphism(rs11209026). Methods:The study included thirty-two AS patients and forty volunteers who serves as a control group. The studied polymorphismwas genotyped using 5 0 Nuclease assay. Results: A statistically significant difference was detected between both studied groups as regards different IL23R genesingle nucleotide polymorphism(rs11209026) genotypes. Heterozygous genotype was the most prevailing among both cases and controls. At a cutoff level of 110 pg/mL, a statically significant difference was observed between cases and controls as regards serum IL23 level. Conclusions:In Egyptians, IL-23R single nucleotide polymorphism (rs11209026) appears to be associated with ankylosing spondylitis occurrence not severity, while higher levels of IL-23 might be associated with disease severity.
Background Lupus nephritis can affect up to 70% of the SLE population elevated serum IL-10 levels were observed in SLE patients and have been shown to be associated with disease activity. It enhances B-cell surivival, proliferation, differentiation, Genotypic variations in the human IL-10 promoter may account for individual variation in IL-10 production and in turn, susceptibility to a particular disease. Objectives to investigate the -592 A/C polymorphism in patients with lupus nephritis with different pathological classes and to assess its influence on IL-10 secretion in vivo. Methods Patients were divided into: – Group I: lupus nephritis group (40 patients). – Group 2: SLE non nephritis group (20 patients). All patients in this study were subjected to the following: Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) Immunological profiles: ANA (Antinuclear Antibody) Anti double stranded DNA titer (Anti-ds DNA) Determination of –592 A/C polymorphisms in the IL-10 gene promoter Detection of serum of IL-10 level. All SLE patients with clinical and laboratory evidence of renal involvement will be subjected to renal core biopsy. Results There is no statistically significant differences in the distribution of the 592 genotypes, or the alleles frequencies between (group 1) and (group 2). There is no statistically significant difference between AC/CC and AA genotypes with different clinical and laboratory parameters in (group 1).Renal biopsy is done for all 40 patients of (group 1). According to the ISN/RPS 2003 classification (96), 12 patients (30%) are classified as class III LN, 16 patients (40%) are classified as class IV LN, 7 patients (17.50) are classified as class V, 4 patients (10%) are classified as class IV+V and 1 patient (2.50%) is classified as class VI. Class I and class II are not detected in the study.According to activity and chronicity indices,(96) class IIIa, IVa and IVa+V are classified as active classes while class IIIc and IVc are classified as chronic classes. There was no statistical significant difference in the distribution of AC and CC genotypes among different LN classes. Decrease in serum level of serum IL-10 in both active and chronic classes of LN does not reach the statistical significance. Conclusions IL-10 gene –592 A/C polymorphism, was not associated with susceptibility to LN or the difference of the patients' serum IL-10 levels, References Lowe PR, Galley HF, Abdel-Fattah A, Webster NR. Influence of interleukin-10 polymorphisms on interleukin-10 expression and survival in critically ill patients. Crit Care Med 2003; 31: 34-8. Lowe PR, Galley HF, Abdel-Fattah A, Webster NR. Influence of interleukin-10 polymorphisms on interleukin-10 expression and survival in critically ill patients. Crit Care Med 2003; 31: 34-8. Disclosure of Interest None declared DOI 10.1136/annrheumdis-2014-eular.3084
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