Background: Recurrent reversible symptoms of hyperresponsiveness of bronchi and obstruction of air flow occur in bronchial asthma which is a chronic airway disease with pathologic inflammation. Objective: To assess the IgE level among asthmatic patients in children. Patients and Methods: our research was conducted on 116 children (87 asthmatic cases and 29 non-asthmatic healthy age and sex matched as control group). This were recruited from Pediatric Department and Outpatient Clinic at Zagazig University Hospital. The cases were subdivided to three groups according to the GINA guide line. They were assessed for the pulmonary functions with assessment of IgE. Results: In terms of IgE levels, statistically significant differences were found between the four groups tested with all asthmatic groups were significantly higher than control group (p < 0.001). Well controlled group had higher values of FEV1% and FVC% with statistically significant difference between asthmatic patients groups. Sensitivity; specificity, PVP and PVN of IgE level were 100.0%, 96.6%, 98.9% and 100% respectively. Conclusion: IgE level can be considered a good predictor for severity of bronchial asthma.
Background: Interleukin (IL) 4 and transforming growth factor β1 (TGF-β1) are two key cytokines involved in a Th2-type inflammation characteristic of asthma. This type has more inflammatory cells that release cytokines which trigger broncho-constriction, mucus over-production, and remodeling of airways which augment inflammatory reactions in asthma. Objective: Our study aimed to verify the association of serum levels of both IL 4 and TGF-β1 with asthma development and further effect on its control level in Egyptian children. Subjects and methods: In this case-control study, two groups of children aged 5-15 years were recruited: first diagnosed as cases of asthma (clinically and spirometry-based); the second group of non-asthmatic children was enrolled as controls. Serum levels of total IgE, IL 4 and TGF-β1 were measured for all children. Cases were classified as controlled, partly controlled and uncontrolled (according to GINA 2008) Results: From December 2013 to Mai 2015, 156 cases and 156 controls were recruited. Serum level of serum total IgE, TGF-β1 and IL4 were significantly higher in asthmatic in comparison to non-asthmatic children. A positive correlation between serum levels of both total IgE and IL-4 and TGF-β1were noted. A higher serum level of total IgE, TGF-β1 and IL4 were noticed in children with poor asthma control.
Conclusion:The data suggests that increased serum levels both TGF-β1 and IL4 in asthmatic children are associated with poor asthma control.
Background: Among children, asthma is the most frequent chronic inflammatory illness with an airway hyper reactivity that leads to blockage and restriction of the airflow. Objective: To detect relation between mannose binding lectin (MBL) genetic polymorphisms and childhood asthma among pediatric population at Zagazig University Hospitals. Patients and methods: 116 individuals were studied in this case-control research, 1 st control healthy group were 29 healthy non-asthmatic of matched age with patients in 2 nd group who were 87 asthmatic children aged between 5 and 15 years old in Zagazig University Pediatric Hospital, Pediatrics Outpatient Clinic. Results: There were statistically significant variations in IgE levels amongst the four groups investigated, with all the asthmatic groups significantly greater than the control group. There was significant difference found between cases and control group according to distribution of MBL2 gene polymorphism, and distribution of MBL2 gene alleles. Conclusion: Our research on elevated levels of MBL and IgE in asthmatics suggests that these antibodies are part of the body's innate immunity, MBL may play a role in asthma pathogenesis by promoting airway inflammation or raising the likelihood of asthma development.
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