Overnight ambulatory pharyngoesophageal manometry is a reliable tool for the exclusion of OSA and identification of severe OSA. It has additional advantages of localizing the level of obstruction and identifying the upper airway resistance syndrome and can be performed at home. It is cost-effective when compared with polysomnography and may aid in treatment selection for individual patients.
Habitual snorers have a long soft palate, a long wide uvula, and a narrowed oropharyngeal isthmus. LAUP shortens and tightens the elongated palate and causes a further reduction in the space between the posterior pillars.
INTRODUCTION: Snoring is a common cause of marital disharmony and social embarrassment. Obstructive sleep apnoea (OSA) have further impact on Quality of Life (QoL). AIMS: First, to compare the impact of snoring and OSA on QoL; second, to assess the impact of laser palatoplasty (LAUP) on QoL in snorers. METHODS: We conducted a prospective cohort comparison of 191 snorers (mean age 46 years; 132 men, 59 women), 57 patients with OSA (mean age 47 years; 49 men, 8 women), and 105 patients, at a mean of 12 months (range, 4-24 months) after LAUP (mean age 45 years; 82 men, 23 women). All completed the Nottingham Health Profile (NHP) and the results were compared with established NHP population norms. RESULTS: The results are shown in Table 1. CONCLUSIONS: This is the largest QoL study of snorers to date and shows that both snoring and OSA have clear impacts on all six NHP domains. The magnitude of the impact in snoring approaches that for OSA for most parameters. The impact of OSA on the sleep domain in men is significantly higher than that of snoring. Energy and emotional reaction domains are significantly improved by LAUP in both sexes, to levels approaching those in the normal population. Also pain, sleep, social isolation and mobility in habitual snorers was helped by surgery. The NHP generic QoL health status measure is a useful tool for the assessment of sleep disorders.
Relationships between the predictive measurements and outcome were at best only weak and none had sufficient predictive value to be useful in clinical practice.
Diabetes mellitus (DM) is the sixth leading cause of death worldwide because of its complications. One of these deadly complications is diabetic nephropathy, the leading cause of end-stage renal disease in the western world. Despite the worldwide acceptance to use albumin-to-creatinine (A/C) ratio and estimated glomerular filtration rate (eGFR) in clinical settings, there is no trustable and valid biochemical marker that can sensitively detect early stages of diabetic nephropathy. Therefore the early detection of the deterioration in kidney function and the changes in kidney structure before the albumin level becomes significantly high in urine is very important for patient's life. The aim of this review is to summarize some novel clinical and molecular markers being investigated as potential candidates to fill in the gap.
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