(10%) patients had HAS-BLED scores of more than 3 (high risk). Bleeding (cerebral, gastrointestinal, or hemoglobin <100 g/L) occurred in 32 (12.3%) patients; 12 (37.5%) of these patients had a HAS-BLED score of more than 3 (p=0.0001). TTR was not different between patients with or without bleeding (64.1+19.4% versus 66.3+16.1%). On the other hand, mean HAS-BLED and ATRIA scores were significantly higher in patients who had bleeding. Using multivariate analysis, ATRIA score followed by HAS-BLED score was the best predictor of bleeding. Age, sex, and TTR as a measure of INR variability did not show a significant difference between the two groups. Conclusion Similar to previous reports of patients with atrial fibrillation, ATRIA and HAS-BLED scores were the best predictors of bleeding in our cohort of patients with mechanical heart valves, with no independent contribution of TTR to estimation of bleeding risk.
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