Background: Head and neck cancer includes several malignancies that originate in the paranasal sinuses, nasal cavity, salivary glands, oral cavity, pharynx, and larynx. The burden of viral infections in cancer is high but underappreciated by much of the cancer research community. Human papilloma virus infection has been postulated to be somehow involved in ameloblastoma etiopathogenesis. Some sudies suggest an association between the presence of viral DNA and aggressive of certain cancers the purpose of this study was to examine the association between HPV and EBV with oral squamous cell carcinoma and ameloblastoma assessed by detection of their DNA in these tissues and to correlate the presence of the viral DNA and aggressiveness of these tumors. Methods: Thirty formalin fixed and paraffin embedded blocks were used in the study. Fifteen of
ـــــــــــــــــــــــــــــــــــ ــــــــــــــــــــــــــــــــــــــــــــــــــــــــ ـ ـ ــــــــــــــــ ـــــــــــــــــــــــــــ Objectives: To assess the efficacy of topical Mitomycin C (MMC) in the treatment of post-intubation tracheal stenosis patients and to report on any complications from its use. Patients and methods: This is a retrospective study in which patients with post-intubation tracheal stenosis who received topical MMC in their management regardless of age and sex were included in the study. All patients had undergone multiple endoscopic dilatation and topical MMC (0.3 mg/mL) application for 2 min Patients who did not show any improvement were scheduled for tracheal resection and anastomosis with application of temporary stent "Montgomery T-tube". Patients developed granulation tissue, managed with the same concentration and duration of MMC. Results: 18 patients had multiple endoscopic dilatation plus MMC application, 11 patients (61.1%) showed an improvement in the degree of airway stenosis. The rest seven patients (38.9%) did not shows any improvement. Six of them undergone tracheal resection and anastomosis, while the seventh patient underwent permanent tracheotomy. All the patients developed granulation tissue after resection and anastomosis and Montgomery T-tube application were treated with endoscopic application of MMC and all of them show complete improvement. We did not report any complications or side effects from the use of MMC intraoperatively or during the followup period. Conclusion: Topical MMC (0.3mg/mL) application could be used safely and effectively in patients who showed initial failed response to MMC after endoscopic dilatation and developed granulation tissue after tracheal resection and anastomosis.
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