Background: Psoriasis is a chronic skin disorder manifested by recurrent episodes of scaly, red, itchy skin patches that occur within apparently normal skin. Objectives: This study was performed to detect the expression of serum and tissue (lesion and non-lesion) LncRNA MALAT-1 and MiRNA-9 that might be used as biomarkers for psoriasis. Methods: 100 subjects were included in this study, 60 psoriatic patients as well as 40 controls, blood samples were taken from all subjects, 4 mm punch biopsy was taken from lesional and non lesional skin of psoriatic patient and controls. Expression of LncRNA MALAT-1 and miRNNA-9 in Serum and tissues was detected by real time qRT-PCR.Results: our results revealed a statistically significant increase in the expression of MALAT-1 in lesional and non-lesional skin and serum of psoriatic patients than controls. Also there was statistically significant increase in serum MiRNA-9 in patients than controls. Meanwhile, its tissue level was significantly decreased in patients than controls.Conclusion: This study highlights the contribution of LncRNA MALAT-1and miRNA-9 in the pathogenesis of psoriasis. Elevated expression of MALAT-1 in lesional skin of psoriatic patients compared to non-lesional skin is probably an important factor in the development of psoriatic plaques.
Various therapeutic options are available for verruca. While physical destruction may be associated with scarring, immunotherapy may be effective in treating warts through stimulating body immune response. The objective of the study was to compare the efficacy, safety, and outcome of Candida antigen vs diphencyprone (DPCP) in the treatment of warts. Fifty patients were randomly assigned to receive either intralesional Candida antigen every 3 weeks or weekly DPCP application. Both treatments were applied only to the mother wart. Lesions’ clearance and associated side effects were observed up to 4 weeks after treatment. Two blinded physicians evaluated photos of warts before and 4 weeks after the end of treatment. Both modalities granted wart clearance and/or improvement with no statistically significant difference; however, Candida antigen was significantly better in clearing adjacent untreated warts (p = 0.046). Fewer side effects were observed among the Candida antigen group. The response was duration associated in the Candida groups only. Intralesional Candida antigen injection and DPCP treatments for warts yielded improvement with superiority of Candida injection in eradicating distant lesions and fewer side effects. A shorter wart duration may be associated with a better therapeutic response with Candida antigen.
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