Background: Nesfatin-1 is nucleobindin 2-derived polypeptide involved in feeding regulation. The expression of Nesfatin-1 in the hypothalamus, pituitary gland and reproductive organs drew the attention to its potential role in regulation of hypothalamic-pituitary-gonadal axis. Yet, very few data are available regarding the effect of gonadal hormones on the regulation of Nesfatin-1. Aim of Study: The present study was designed to explore the probable sex difference in serum Nesfatin-1 levels and the relationship between serum levels of sex hormones and Nesfatin-1 in adult male and female albino rats. Material and Methods: The study involved 18 male and 30 female albino rats. The male rats were divided in to three equal groups: Control (M Cont.), orchidectomized (ORX), and testosterone-treated orchidectomized (T-treated ORX). The female rats were divided in to five equal groups: Control (F Cont.), ovariectomized (OVX), estradiol-treated ovariectomized (E-treated OVX), progesterone-treated ovariectomized (P-treated OVX), and estradiol and progesterone-treated ovariectomized (E + P-treated OVX). Serum levels of Nesfatin-1, LH (in all rats), testosterone (in male rats), estradiol and progesterone (in female rats) were measured. Results: Serum levels of Nesfatin-1 were higher in female than in male control rats. Nesfatin-1 levels significantly decreased in ORX group compared with M Cont. group and increased in T-treated ORX group compared with ORX group. Nesfatin-1 positively correlated with testosterone in ORX and T-treated ORX groups, but insignificantly correlated with LH in all groups. Serum levels of Nesfatin-1 were significantly decreased in OVX group compared with F Cont. group and increased in E-treated OVX, P-treated OVX and In E + Ptreated OVX groups when compared with those of OVX group. Positive correlations were found between Nesfatin-1 and both estradiol and progesterone in OVX, E-treated OVX, P-treated OVX, and E+P-treated OVX groups; however, no significant correlations were found with LH in all groups. Conclusion: From the above results it can be concluded that gonadal hormones are important regulators of serum levels of Nesfatin-1 in albino rats.
A 3×3 factorial experiment was performed to study the effect of supplementing broiler diets with different levels of Mannan-oligosaccharides (MOS) (0, 4 and 8 g/kg diet), Enterococcus faecium (E.f) (0, 1×10 9 and 2×10 9 CFU/kg diet) and their combination on growth performance and carcass traits of broiler chickens. A total number of 360 1-week-old broilers were randomly distributed to 9 equal groups, each group contained 40 unsexed birds with 4 replications (10 birds each). Results showed that average live body weight (LBW), body weight gain (BWG) and feed conversion ratio (FCR) of broiler chicks received diets containing 4 and 8 g MOS/kg were better than control group. While feed intake (FI) was not significantly affected by different levels of dietary MOS. The addition of 1×10 9 CFU of E.f to the basal diet of broiler chicks insignificantly enhanced the increase of LBW, BWG and FCR, while the addition of 2×10 9 CFU of E.f significantly increased LBW, BWG and FCR, as compared to control. No significant differences were found between groups treated with tested probiotic in LBW, BWG and FCR. The amount of feed consumed through the experiment was not significantly affected with E.f supplementation at different levels. No significant effects were detected due to dietary treatment with MOS, E.f or their interaction on all studied carcass traits (carcass, liver, gizzard, heart, total giblets and dressing percentages). The results indicated that supplementing broiler diets with different levels of MOS, E.f and their combination has positive effect on growth performance with no significant effect on carcass traits.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.