Background In this study, we aimed to evaluate the effects of tocilizumab in adult patients admitted to hospital with COVID-19 with both hypoxia and systemic inflammation. Methods This randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing several possible treatments in patients hospitalised with COVID-19 in the UK. Those trial participants with hypoxia (oxygen saturation <92% on air or requiring oxygen therapy) and evidence of systemic inflammation (C-reactive protein ≥75 mg/L) were eligible for random assignment in a 1:1 ratio to usual standard of care alone versus usual standard of care plus tocilizumab at a dose of 400 mg–800 mg (depending on weight) given intravenously. A second dose could be given 12–24 h later if the patient's condition had not improved. The primary outcome was 28-day mortality, assessed in the intention-to-treat population. The trial is registered with ISRCTN (50189673) and ClinicalTrials.gov ( NCT04381936 ). Findings Between April 23, 2020, and Jan 24, 2021, 4116 adults of 21 550 patients enrolled into the RECOVERY trial were included in the assessment of tocilizumab, including 3385 (82%) patients receiving systemic corticosteroids. Overall, 621 (31%) of the 2022 patients allocated tocilizumab and 729 (35%) of the 2094 patients allocated to usual care died within 28 days (rate ratio 0·85; 95% CI 0·76–0·94; p=0·0028). Consistent results were seen in all prespecified subgroups of patients, including those receiving systemic corticosteroids. Patients allocated to tocilizumab were more likely to be discharged from hospital within 28 days (57% vs 50%; rate ratio 1·22; 1·12–1·33; p<0·0001). Among those not receiving invasive mechanical ventilation at baseline, patients allocated tocilizumab were less likely to reach the composite endpoint of invasive mechanical ventilation or death (35% vs 42%; risk ratio 0·84; 95% CI 0·77–0·92; p<0·0001). Interpretation In hospitalised COVID-19 patients with hypoxia and systemic inflammation, tocilizumab improved survival and other clinical outcomes. These benefits were seen regardless of the amount of respiratory support and were additional to the benefits of systemic corticosteroids. Funding UK Research and Innovation (Medical Research Council) and National Institute of Health Research.

Purpose The purpose of this paper is to examine the representation of women in Canadian broadcast news coverage, exploring the notion of substantive representation as it relates to gender, leadership and framing. Design/methodology/approach Using computer-aided text analysis software, the authors analyzed the frequency of women appearing in on-air roles, the way in which they are framed, as well as technical and expressive details, such as how they are featured. In total, the authors analyzed representation of 2,031 individuals in the four suppertime local news broadcasts from 6 p.m. to 7 p.m. Framed in an ecological model of complex social change, this paper focuses on understanding how women are presented in Canadian broadcast media. Findings This study finds that women are under-represented in Canadian broadcast media. Furthermore, it finds that women are less likely to be framed as leaders or experts and are less likely to hold news host or anchor positions. For all major news broadcasters analyzed, women are less likely to be portrayed positively or in leadership/expert positions and are more often represented as victims. They are less likely to appear on screen and are more likely to be referred to off-screen, paraphrased and cited rather than speaking for themselves. Research limitations/implications By framing this study in an (critical) ecological, this study moved beyond required descriptive benchmarking to examine the degree of substantive representation of women. However, the sample of the study is only a snapshot of Canada’s largest city, and, therefore, more research involving further a comparative analysis of cities, a variety of print sources and online media outlets is needed. Future research might include more qualitative analysis of the representation, the type of representation and the factors affecting levels of representation. For example, such research might explore the practices in broadcast organizations, the way in which stories are framed and how guests selected. Also of interest is the relationship between women’s representation at the decision-making table, as an input, and the representation of women in on-air roles, as an outcome. Practical implications The implications of this article are important for understanding the complex factors affecting female leadership across sectors, particularly, the Canadian broadcast industry, the barriers they face and the strategies that may lead to their advancement. Originality/value This study moved beyond descriptive benchmarking to examine the degree of substantive representation of women by coding the frames, roles and means of quotation experienced by women on broadcast news.

<abstract> <p>Biofilms are aggregates of bacteria, in most cases, which are resistant usually to broad-spectrum antibiotics in their typical concentrations or even in higher doses. A trend of increasing multi-drug resistance in biofilms, which are responsible for emerging life-threatening nosocomial infections, is becoming a serious problem. Biofilms, however, are at various sensitivity levels to environmental factors and are versatile in infectivity depending on virulence factors. This review presents the fundamental information about biofilms: formation, antibiotic resistance, impacts on public health and alternatives to conventional approaches. Novel developments in micro-biosystems that help reveal the new treatment tools by sensing and characterization of biofilms will also be discussed. Understanding the formation, structure, physiology and properties of biofilms better helps eliminate them by the usage of appropriate antibiotics or their control by novel therapy approaches, such as anti-biofilm molecules, effective gene editing, drug-delivery systems and probiotics.</p> </abstract>

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As of our most recent census data, racialized people comprise 22.3% of the Canadian population (Statistics Canada, 2016). Canadian universities have espoused commitments to diversity and inclusion but there has long been a gap between the rhetoric and practice. Research has demonstrated that under-representation is a problem at all levels of academia but particularly within the senior ranks. Drawing on an original dataset representing 324 senior university leaders, this study will empirically map the demographic composition of academic leaders across Canada, including presidents, vice-presidents, assistant vice-presidents, associate vice-presidents, provosts, and vice-provosts. Our findings suggest that racialized people in leadership are under-represented compared with their presence in the university population—consistent with the pyramid of exclusion where the representation of racialized people decreases as we move up the ranks. Taking a systems perspective informed by our critical ecology model we examine the overlapping societal-, organizational-, and individual-level mechanisms that impede the advancement of racialized people into leadership positions at universities in Canada.