This study was carried out to illustrate seroprevalence of Toxoplasma gondii and Brucella melitensis in local sheep and goat flocks living in Nile Delta regions of Egypt as well as to investigate its effects on animals' health and performance. In trial 1: 492 serum samples were collected from domestic ewes and does flocks suffering from abortion and stillbirths were used in this survey. In trial (2): 100 serum samples collected from toxoplasma or brucella infected or non infected sheep and goats were used to study the effects of toxoplasmosis and brucellosis on animals , health. This study revealed that 142 (28.86%) sera contained antibodies against Toxoplasma gondii and 89 (18.09%) were positive for Brucella melitensis. The incidences of toxoplasmosis and brucellosis were 31.01% and 12.26% in sheep, respectively and 17.11% and 36.84% in goats, respectively. Higher seroprevalence of Toxoplasma gondii was recorded in sheep with high flock size. Farmers using set stocking management had lower seroprevalence toxoplasmosis and brucellosis. Toxoplasmosis and brucellosis lowered serum albumin level and liver enzymes activities while, increased serum levels of globulin, urea, triglyceride and cholesterol in ewes. Serum levels of total protein, albumin and urea and the activity of serum aspartate amino transferase were decreased, however serum level of C reactive protein was increased in infected does. These results indicated that toxoplasmosis is widely spread than brucellosis in small ruminants living in the provinces of Nile Delta. Both toxoplasmosis and brucellosis inversely affected animals' health. Management practices had a role in spread of these agents.