New neurons are generated in the adult hippocampus of many species including rodents, monkeys, and humans. Conditions associated with major depression, such as social stress, suppress hippocampal neurogenesis in rodents and primates. In contrast, all classes of antidepressants stimulate neuronal generation, and the behavioral effects of these medications are abolished when neurogenesis is blocked. These findings generated the hypothesis that induction of neurogenesis is a necessary component in the mechanism of action of antidepressant treatments. To date, the effects of antidepressants on newborn neurons have been reported only in rodents and tree shrews. This study examines whether neurogenesis is increased in nonhuman primates after antidepressant treatment. Adult monkeys received repeated electroconvulsive shock (ECS), which is the animal analog of electroconvulsive therapy (ECT), the most effective short-term antidepressant. Compared with control conditions, ECS robustly increased precursor cell proliferation in the subgranular zone (SGZ) of the dentate gyrus in the monkey hippocampus. A majority of these precursors differentiated into neurons or endothelial cells, while a few matured into glial cells. The ECS-mediated induction of cell proliferation and neurogenesis was accompanied by increased immunoreactivity for the neuroprotective gene product BCL2 (B cell chronic lymphocytic lymphoma 2) in the SGZ. The ECS interventions were not accompanied by increased hippocampal cell death or injury. This study demonstrates that ECS is capable of inducing neurogenesis in the nonhuman primate hippocampus and supports the possibility that antidepressant interventions produce similar alterations in the human brain.

Purpose Many companies invest in innovations because of the inherent benefits, and research on innovation has increased over the year. However, the vast majority of research papers deals with purely technical matters. There seem to be growing concerns over ethical issues in adopting innovations in the construction industry. This extant review of literature aims to analyse the interrelations between the concepts of ethics and innovations in construction research to understand the advances of current scientific production and future lines of research. Design/methodology/approach Thus, this work presents a bibliometric analysis covering articles obtained from the Web of Science Core Collection Database published between 1995 and May 2021. A sample size of 5,786 research papers relevant to the study was evaluated using VOSviewer software. Findings The results of the analysis shed light on the evolution of the connection between the two concepts. The study highlighted Heng Li as the most productive author. The country with the most publications and citations is China. The most productive institution is the Hong Kong Polytechnic University. The results revealed a limited intellectual exchange and lack of cohesion characterising the two concepts (ethics and innovation), resulting in a situation whereby innovation-related researchers tend to follow personal trajectories in isolation from ethics-related researchers in the construction field. Originality/value This is probably the most comprehensive scientometric analysis ever conducted to examine the theoretical relationship between ethics and innovation in construction. This study adds to the so far limited knowledge in the field and provides insights for future research. Overall, this review may spur future research on dyad investigation of ethics and innovative related themes in construction such as ethics and sustainability, ethics and sensor-based technology and ethics and innovative safety approach.

Risk management is a critical function in banking operations in the wake of several banking crises. However, we find few studies on risk management and a lack of empirical investigation on factors affecting the risk of Malaysian banks. These gaps have motivated us to identify the main factors associated with the risk of locally listed deposit-taking institutions. The findings show that three factors were significantly associated with unsystematic risk, while the systematic risk and the total risk of these deposit-taking institutions were significantly affected by four main factors. These four factors namely non-performing loans, cost of funds, loan to deposit ratio and inter-bank offered rate however, were found to have a more profound effect on the total risk than on the systematic risk or the unsystematic risk of Malaysian deposit-taking institutions.

Posterior reversible encephalopathy syndrome with spinal cord involvement (PRES-SCI) is a recently described entity with a handful of cases reported in literature. We describe a case of PRES in setting of Henoch-Schönlein purpura (HSP) with involvement of brain stem and spinal cord.

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