Prepubertal periodontitis (PPP) is a rare and rapidly progressive disease of young children that results in destruction of the periodontal support of the primary dentition. The condition may occur as part of a recognised syndrome or may occur as an isolated finding. Both autosomal dominant and recessive forms of Mendelian transmission have been reported for PPP. We report a consanguineous Jordanian family with four members aVected by PPP in two nuclear sibships. The parents of the aVected subjects are first cousins. We have localised a gene of major eVect for PPP in this kindred (Zmax=3.55 for D11S901 at =0.00) to a 14 cM genetic interval on chromosome 11q14 flanked by D11S916 and D11S1367. This PPP candidate interval overlaps the region of chromosome 11q14 that contains the cathepsin C gene responsible for Papillon-Lefèvre and Haim-Munk syndromes. Sequence analysis of the cathepsin C gene from PPP aVected subjects from this Jordanian family indicated that all were homozygous for a missense mutation (1040A→G) that changes a tyrosine to a cysteine. All four parents were heterozygous carriers of this Tyr347Cys cathepsin C mutation. None of the family members who were heterozygous carriers for this mutation showed any clinical findings of PPP. None of the 50 controls tested were found to have this Tyr347Cys mutation. This is the first reported gene mutation for nonsyndromic periodontitis and shows that non-syndromic PPP is an allelic variant of the type IV palmoplantar ectodermal dysplasias. (J Med Genet 2000;37:95-101)

No abstract

This study reveals that socio-economic status is a major factor influencing the occurrence of pediculosis among school students of both sexes in Jordan. A national campaign should be implemented to enhance public awareness.

Ingestion of Frankincense [Boswellia thurifera (B. thurifera)] resin at a dose of 250 and 500 mg/kg body weight for 60 days by adult male rats was investigated for effects on fertility. Average weights of epididymis, ventral prostate and seminal vesicles increased significantly. Sperm motility and density were also significantly increased in cauda epididymis and in testes in Frankincense-treated groups. A significant increase of spermatogenesis in testes due to increase in the number of primary, secondary spermatocytes and spermatids in the treatment groups was attributed to a significant increase in testosterone and Follicle stimulating hormone (FSH). In addition, it also increased the number of implantations and the number of viable fetuses in female rats impregnated by these males, thereby increasing their fertility. The histometery of reproductive organs confirmed those results.

Background Celiac disease (CD) emerged as a public health problem, and the disease prevalence varies among different races. The present study was designed to investigate the prevalence of CD using serological markers in apparently healthy schoolchildren in Irbid City, Jordan. Additionally, the effect of positive serology on height, weight and body mass index (BMI) was evaluated. Methods The study population consisted of 1985 children (1117 girls and 868 boys), age range was 5.5 to 9.5 years. Height and weight were measured and blood samples were collected from each individual. Serum samples were analyzed for IgA anti-tissue transglutaminase antibodies (tTG) using a commercial enzyme-linked immunosorbent assay (ELISA). tTG positive samples were further analyzed for IgA anti-endomysium antibodies (EmA) with a commercial ELISA. Samples confirmed positive with EmA were considered seropositive. Results Sixteen children were CD positive. The serological prevalence was estimated to be 1:124 (0.8%; 95% CI, 0.5% to 1.3%). Significant impact on growth (height) was found in seropositive children. When both sexes were individually analyzed, only boys showed height reduction. Furthermore, seropositive boys also had a significant weight reduction. Conclusion This study demonstrated that CD is prevalent among schoolchildren in Jordan. The seropositive children tend to have lower height, weight, and BMI than the seronegative group. These differences were significant only for boys. None of the participants is known to have CD prior to the study.