A series of new polysubstituted derivatives of 2-tetralones possessing two ester 1 groups were synthesized via a tandem aldol condensation-Diels-Alder-aromatization 2 sequence of reactions. All the three steps took place in one pot and in the presence of 3 aminofunctionalized silica coated Fe 3 O 4 nanoparticles as the catalyst. In situ formed dienes 4 reacted with diethyl acetylenedicarboxylate at room temperature and the process was followed 5 by spontaneous aromatization of the cycloadducts to produce high yields of the final tetralone 6products. Further studies suggest that the process goes through an initial aldol condensation-7 cycloaddition sequence followed by oxidation and rearrangement steps. After completion of 8 the reactions, the catalyst could be recycled and reused efficiently in next reactions. 910
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.