Objective To assess the effect of a multifaceted intervention directed at general practitioners on six year mortality, morbidity, and risk factors of patients with newly diagnosed type 2 diabetes.Design Pragmatic, open, controlled trial with randomisation of practices to structured personal care or routine care; analysis after 6 years. Setting 311 Danish practices with 474 general practitioners (243 in intervention group and 231 in comparison group). Participants 874 (90.1%) of 970 patients aged >40 years who had diabetes diagnosed in 1989-91 and survived until six year follow up. Intervention Regular follow up and individualised goal setting supported by prompting of doctors, clinical guidelines, feedback, and continuing medical education. Main outcome measures Predefined clinical non-fatal outcomes, overall mortality, risk factors, and weight. Results Predefined non-fatal outcomes and mortality were the same in both groups. The following risk factor levels were lower for intervention patients than for comparison patients (median values): fasting plasma glucose concentration (7.9 v 8.7 mmol/l, P = 0.0007), glycated haemoglobin (8.5% v 9.0%, P < 0.0001; reference range 5.4-7.4%), systolic blood pressure (145 v 150 mm Hg, P = 0.0004), and cholesterol concentration (6.0 v 6

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Regular measurements of hemoglobin A1c lead to changes in diabetes treatment and improvement of metabolic control, indicated by a lowering of hemoglobin A1c values.

Increased serum levels of CK-MB mass, troponin T and myosin light chains all detect a subgroup of 25% of patients without acute myocardial infarction who have as poor a prognosis as that of patients with a definite diagnosis of acute myocardial infarction. All three biochemical markers provide similar important independent prognostic information with regard to clinical findings and arrhythmias but add no additional prognostic information once ECG ST-T wave changes are considered.