Various ethnics of the world have a long history on using their surrounding as the source of foods. Foods which are act as product of traditional ethnic knowledge known as traditional and ethnic foods (TEF). Vegetables are one of the main ingredients of TEF. As sources of many combination of phytonutrients, vegetables offer various health benefits. As a country with long history of agricultural practice, Indonesia also has abundant knowledge of how Indonesian ethnics process and consume vegetables.Vegetables, in Sundanese tradition, usually consumed as “lalap” or “lalapan”. Some lalapan are cultivated vegetables and some others are come from wild sources. This article discuss the health benefits of wild source lalapan, which can be found in natural habitat.

Hair loss is a hair problem that often occurs in every individual. Side effects caused by the use of synthetic drugs cause herbal remedies to be an option in overcoming hair loss and to stimulate hair growth. Rampai leaves (Lycopersicon esculentum Mill.) has traditionally been used to stimulate hair growth in the Lampung tribe. This study aim was to examine the activity of hair growth stimulation effects of ethanol extract and fraction (n-hexane, ethyl acetate, and water) from rampai leaves. The activity test of hair growth stimulation effect was carried out topically on New Zealand White (NZW) male rabbits for 21 days with the modified Tanaka method and using 2% minoxidil as a positive control The analysis results were evaluated statistically. The test results of ethanol extract of rampai leaves showed the most significant hair growth stimulation activity at 10% concentration, followed by a concentration of 20% and 5%. In testing the activity of fraction, n-hexane fraction significantly showed better hair growth activity compared to ethyl acetate, water fractions, and positive control. This showed that rampai leaves had vity of hair growth stimulation effects could be used as anti-alopecia treatment. Further experiments are needed to find the chemical compound content that is responsible for the nature of hair growth.

AbstrakSenyawa triterpenoid damaran, damara-20,24-dien-3-on telah diisolasi dari kulit batang Chisocheton Marcrophyllus (Meliaceae). Struktur kimia kedua senyawa tersebut telah ditetapkan berdasarkan data spektroskopi dan perbandingan data spektra yang diperoleh dari literatur. Senyawa damara-20,24-dien-3-on menunjukkan aktivitas sitotoksik terhadap sel kanker payudara manusia MCF-7 dengan nilai IC50 28 mM.Kata Kunci : aktivitas sitotoksik, sel MCF-7, triterpenoid damaran, Chisocheton Marcrophyllus,  MeliaceaeAbstractDammarane triterpenoid, damara-20,24-dien-3-on has been isolated from the bark of Chisocheton Marcrophyllus (Meliaceae). Chemical Structure of compound was dtermined on the basic of spektroscopic data and comparison with those spectra data previously reported. Compound damara-20,24-dien-3-on exhibited cytotoxic activity againts MCF-7 human breast cancer cell lines with IC50 value 28 mM respectively.Kata Kunci : cytotoxic activity, MCF-7 cell, dammarane triterpenoid, Chisocheton Marcrophyllus,  Meliaceae

Drugs consultation by pharmacist is an important service to improve the quality of medication use in patients with type 2 diabetes mellitus (T2DM). Perception of patients regarding this service is very useful to boost pharmacists confidence to conduct such service. The purpose of this study is to provide an overview regarding interests and categories of drugs consultation needed by T2DM patients and to determine the effect of quality of drugs consultation on patients interest to participate in such program. Survey and interviews were conducted with T2DM patients in outpatient clinic, Dr. M. Salamun Air Force Hospital, Bandung during April-June 2013. One hundred patients were recruited for this study. Most of the patients consumed combination of oral antidiabetic and non-antidiabetic medication (71 %) and were given polypharmacy (45 %). The results showed that the information regarding drugs interactions, adverse drugs reaction (ADR), and drugs dosage were among the aspects that should be included in drugs consultation service by pharmacists. The quality of drug information service was associated with increased interest to participate in such program. These aspects should be considered in the implementation of drugs consultation program by pharmacists.

Objective: This study aims to find antimalarial candidates from 32 terpenoids and three flavonoid compounds found in miana leaves in silico using plasmepsin protein as a receptor through docking simulations, molecular dynamics simulations, and pharmacokinetic predictions. Methods: The research was conducted in silico through molecular docking simulation, molecular dynamic simulations, analysis of potential compounds using Lipinski’s rule, and prediction of ADMET based on ligands. Results: The results showed isophytol had the best interaction with the plasmepsin II based on the low free binding energy (FBE) and led to hydrogen bonding with the plasmepsin II crucial amino acid, Asp34. Isophytol has the best result in molecular dynamic simulation. Based on pharmacokinetics predictions, toxicity, and Lipinski’s rule of five, most tested compounds, including isophytol, meet the criteria as a promising drug. Conclusion: Isophytol from miana leaves with plasmepsin II protein has the best and most stable interaction based on the results of molecular dynamic simulation, so this compound was a candidate for antimalarial drugs.

Crotalaria pallida Aiton (C. pallida Aiton) is empirically used as dietary supplement to treat cancer by the people of North Sulawesi. However, its scientific pharmacology activity has not been explored yet. Therefore, this study was conducted to evaluate anti-proliferative activity of C. pallida Aiton on MCF-7 breast cancer cells. The extraction of leaves and seeds were performed using ethanol, ethyl acetate, n-hexane, and water. Phytochemical screening was then performed to identify secondary metabolites in this extract. Anti-proliferative activity was evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The results indicated that ethyl acetate fraction of C. pallida Aiton has the lowest IC 50 (29,67). In conclusion, ethyl acetate fraction of C. pallida Aiton is potential to be developed as anti cancer agent.

The aim of this study was to investigate medicinal plants used to treat malaria by a society in Pamotan village, Pangandaran Regency, West Java Province, Indonesia. The work was conducted using the Participatory Rural Appraisal (PRA) method, which is an assessment process-oriented to active community involvement in the form of direct interview activities. Information was collected by interviewing respondents using a semi-structured questionnaire. Interviews were directed to the plants used to prevent and overcome malaria by referring to the list of questions which included the local name of the plant, the part used and the method of preparation and administration. A total of 47 respondents were interviewed of which 43% were females and 57% males. Results indicated that thirteen species of plants belonging were used to treat malaria by the villagers of Pamotan. The three plants that have the highest citation frequency are bitter herbs (Andrographis paniculata Ness.) 35.71%, papaya leaves (Carica papaya L.) 21.43%, and cut leaf ground cherry whole plants (Physalis angulata L.) 21.43%. The most common preparation method is decoction and the route of administration is oral. It is concluded that the Pamotan villagers in Pangandaran district, Indonesia, still use ingredients from plants as complementary medicine to treat malaria.

Most of the studies report that species of the Corynebacterium genus are generally causal bacteria of axillary odor, by converting odorless secretions compounds into odorous volatile molecules. The aim of this work was to provide information on the chemical compounds in the essential oil of Indonesian patchouli leaf (Pogostemon cablin (Blanco) Benth) that demonstrated the antibacterial activity against Corynebacterium sp. clinical isolate. The Corynebacterium sp. was isolated from basketball players' armpits and identified by observing the specific colonies characteristics on the blood agar. The chemical compounds were characterized using gas chromatography coupled to mass spectrometer (GC-MS). The antibacterial activity was performed according to the procedures of the Clinical and Laboratory Standards Institute. According to GC-MS result, the essential oil of Indonesian patchouli leaf presented 62 different compounds with the majorities as the following compounds: patchouli alcohol (21.00%), 1H-benzocycloheptene, 2,4a, 6,6,7,8-hexahydro-3,5,5,9-tetramethyl- (18.70%), caryophyllene (5.36%), seychellene (4.24%) and cyclohexene,1-methyl-4-(5-methyl-1-methylene-4-hexenyl) (3.01%). The integration of these compounds potentiates the antibacterial activity of the essential oil with lower concentration than 10 % v/v. Therefore, the essential oil of Indonesian patchouli leaf presented the significant antibacterial activity against Corynebacterium sp. as the causative agent of axillary odor.