The anti-inflammatory drug, Diclofenac (DIC) anion, was intercalated into the layered zinc hydroxide (LZH) by ion-exchange method. Then, the DIC-LZH/ Chitosan nanocomposite was prepared by coating of Chitosan on DIC-LZH. LZH intercalated with DIC was successfully encapsulated into Chitosan by precipitation method. The structures of the obtained products were studied by powder X-ray diffraction, FT-IR spectroscopy, scanning electron microscopy, and thermal analysis. The XRD patterns and FTIR analyses showed that the DIC was successfully intercalated into the LZH interlayer space with an average basal spacing of 29.42 Å . Thermal analysis studies confirmed that the thermal stability of DIC was enhanced after intercalation into LZH. In addition, drug release behaviors in vitro of DIC from DIC-LZH and DIC-LZH/Chitosan nanocomposites were observed in phosphate buffer solution under the conditions of pH 4.8 and 7.4, respectively.
The intercalation of amoxicillin trihydrate (AMOX) into layered zinc hydroxide (LZH) has been achieved via ion-exchange method. The resulted nanocomposite (AMOX-LZH) has been thoroughly characterised by a number of techniques including powder X-ray diffraction (PXRD), FT-IR spectroscopy, TGA/DTG analysis and scanning electron microscopy (SEM). The PXRD results showed that the gallery height of LZH was expanded from 9.57 to 11.97 A , indicating that the AMOX anions were successfully intercalated into the interlayer space of LZHs. The increased thermal stability of nanocomposite was confirmed by TGA/ DTG analyses. Improved antibacterial activity and minimum inhibitory concentration of AMOX-LZH nanocomposite was evaluated against Grampositive bacteria Staphylococcus aureus, Klebsiella pneumonia and Gram-negative Escherichia coli using the disk diffusion technique. The sustained release of amoxicillin drug from the AMOX-LZH nanocomposite was also verified.
The title complex, (C8H20N)2[MoS4(CuCN)2]·H2O, contains an anion in which Cu atoms bridge two opposite S⋯S edges of the central MoS4 unit. The Mo atom retains tetrahedral coordination geometry, while each Cu is trigonal planar coordinated by two bridging sulfides and a terminal cyano ligand. The anions are linked together into chains by hydrogen bonding to ordered water molecules.
Key indicatorsSingle-crystal X-ray study T = 150 K Mean '(C±C) = 0.006 A Ê R factor = 0.033 wR factor = 0.071 Data-to-parameter ratio = 19.2 For details of how these key indicators were automatically derived from the article, seeThe molecular structure of (I), with atom labels and 50% probability ellipsoids for non-H atoms.
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