Introduction: Measures of carotid artery flow or inferior vena cava diameter were recently shown to predict fluid responsiveness. Both are relatively superficial large vessels which can provide straightforward ultrasound evaluation & high-qualityimages.Methods: Our study is a prospective observational study on 30 mechanically ventilated septic shock patients in ICUto assess the fluid responsivenessby measuring carotid Doppler peak velocity&respiratory variation in inferior vena cava diameter against the increase in the cardiac index by echocardiographic calculations as a reference. All patients were given a fluid bolus 7 ml/ Kg crystalloid solution within 30 minutes, static and dynamic indices which include CVP, MAP, pulse pressure, difference between diameter of IVC during inspiration and expiration (ΔIVC- d) & carotid Doppler peak velocity in a single respiratory cycle (ΔCDPV) were measured before (T0) & after (T1). Vasoactive drugs infusion rate and ventilation settings did not changed during follow up. Patients were categorized either fluid responders “R” or non-responders “NR” according to an increase in cardiac output “CO” (increase in CO > 15 %.Results: Comparing responders & Non responders group we found a significant difference in Cardiac output measures,MAP & Δ CDPV pre & post fluid boluses as (5.26±4.42 L/min Vs. 10.62±5.73 L/min, 69.48±9.70 mmHg Vs. 84.90±10.36 mmHg&24.43±11.87%Vs33.22±11.00%) respectively with P-value (0.007, 0.05&0.01) respectively, on the other side , ΔD-IVC & Δ CVP pre & post fluid boluses didn’t show any statistical difference as (11.91±9.41 % Vs. 13.51±9.56 %, 5.86±5.22 cmH2O Vs 7.22±4.82 cmH2O) with P-value (0.87&0.68)respectively.Δ CDPV increase in response to increased intravascular volume in R group showed sensitivity 81%, specificity 66.7%. APACHE II, SOFA day 0,5 didn’t showed any difference between the R & NR group (16.05±3.23 Vs 18.44±3.81, 11.48±2.82Vs12.11±2.80& 12.95±3.68Vs12.56±3.97) respectively with P-value (0.164,  0.625 & 0.79) respectively. Conclusion: ΔCDPV was a more precise & even easier assessment tool with better sensitivity and specificity for evaluation of fluid responsiveness than the ΔD-IVC in patients with septic shock upon mechanicalventilation. Also, ΔCDPV has a high correlation with SVI increasing parameters assessed by echocardiography after fluid boluses. On the other hand and in comparison, CVP showed low accuracy in predicting fluid responsiveness.  

Background: Kidney transplant recipients may develop post-transplant diabetes mellitus (PTDM). Dipeptidyl peptidase 4(DPP-4) inhibitors are evolving agents in the management of patients with diabetes mellitus. Aims: To evaluate the efficacy and safety of DPP-4 inhibitors in the management of post-transplant diabetes mellitus (PTDM) in renal transplant recipients. Methods: We performed a systematic search of the electronic databases using keys words and Mesh terms. Data were extracted and reviewed using structured proforma. A comprehensive review of the eligible studies was performed independently by each of two reviewers; conflicts were resolved by the third reviewer. The primary efficacy endpoint was the difference in glycosylated hemoglobin (HbA1c) comparing any of the DPP-4 inhibitors to either placebo or other hypoglycaemic agent. The primary safety endpoints were the worsening of graft functions and change in Tacrolimus trough level. We performed the Random effect model using standardised mean difference. Results: We identified seven studies that were eligible for the systematic review; only one study compared Sitagliptin to insulin Glargine. One study involved head to head comparison of three DPP-4 inhibitors. The other five studies were pooled in the meta-analysis. DPP-4 inhibitors had a favourable glycemic effect as measured by HbA1c when compared to either placebo or oral anti-hyperglycemic medications (standardised mean difference in HbA1c = -0.993, 95% CI= -1.303 to -0.683, P=0.001). DPP-4 inhibitors use did not result in significant change in eGFR ((standardised mean difference = 0.147, 95% CI= -0.139 - 0.433, p=0.312).) nor Tacrolimus level (standardised Mean Difference= 0.152, 95% CI= -0.172 to 0.477, P=0.354). Conclusion: Current evidence supports the short term efficacy and safety of DDP-4 inhibitor agents in the management of post transplantation diabetes mellitus (PTDM) in kidney transplant recipients. However, more RCTs are required to investigate the long-term safety and efficacy of these agents in kidney transplant recipients.

Coronavirus Disease 2019 (COVID-19) had struck the world with health and economic catastrophes and recently with unusual autoimmune presentations, including new-onset Type 1 Diabetes. Herein we present a 17-year-old male patient who presented to the Emergency room with fever, palpitation, and cough of four-week duration; he was referred to the Emergency room and was found to have DKA. CT of the chest showed ground-glass opacities suggestive of COVID-19 pneumonia, and abdominal cuts showed dilated intrahepatic biliary radicles with pancreatic loculations suggestive of pancreatitis. The patient was admitted to the ICU, started on Intravenous fluids and Insulin infusion then COVID-19 PCR returned positive. We hypothesize that SARS-CoV-2 has a vital role in eliciting an autoimmune response triggering Type 1 Diabetes, and further studies are needed to confirm this hypothesis. SARS-COV-2 may cause pancreatitis, and the first presentation could be high blood sugar or DKA.

Objectives: Percutaneous kidney biopsy is a useful diagnostic procedure. Hemorrhagic complications may occur following the procedure. Methods: We retrospectively analyzed the records of 1198 patients who had percutaneous renal biopsy between March 2013 and March 2018. The cohort included both native kidney and transplant biopsies. We have included only the first biopsy for each patient; repeat biopsies for 132 patients were excluded from the analysis. Results: 1198 patients ( 332 transplant recipients and 886 native kidney patients) were included in the study. Major complications occurred in 18(1.5%) of patients (1.4% in native kidney biopsies Vs 1.6% in kidney transplant recipients. Adequate renal tissue (core of > 6 glomeruli ) was obtained in 91 % of patients. Our analysis revealed that the incidence of major complications, in the native kidney biopsy are increased with age>65 years (odds ratio2.4, 95 % CI (1.5-5.6), eGFR<30 ml/min/m2 (odds ratio 9.7, 95 % CI (3.4-18.2)  ) and anemia(9-11 mg/dl)(odds ratio3.2 (1.7-5.2), 95 % CI(1.7-5.2). In transplant recipients kidney biopsy the incidence of complications was increased with age>65 years (odds ratio 2.8(1.7-7.3), 95 % CI (1.7-7.3), eGFR<30 ml/min/m2 (odds ratio 11.3, 95 % CI  (3.5-16.8 ) and anemia (9-11mg/dl )(odds ratio 2.4, 95 %(1.7-4.7). Conclusion: The incidence of major complications following kidney biopsy was 1,5%(for  a cohort of native kidney biopsy and kidney transplant  biopsies . Age> 65 years, lower eGFR < <30 ml/min/m2 and anemia were independent risk predictors for the occurrence of major complications in both native and transplant kidney biopsy. Keywords: Biopsy; biopsy, needle; renal, complications, safety, adequacy.

Highlights Abstract Background: End-stage renal disease (ESRD) is a growing global health hazard. Most patients are maintained on dialysis rather than transplantation. Adequate vascular access for hemodialysis is crucial to achieve an optimal dialysis dose and to reduce morbidity and mortality. Patients with multiple access failure are in desperate need for lifesaving access, especially in the absence of alternatives (transplantation or peritoneal dialysis). Objective: Patients with multiple vascular access failure and exhausted approachable veins are being referred to an interventional nephrology or radiology centers. The aim of this work is to evaluate a single center’s experience of sophisticated venous approaches to provide access for hemodialysis. Methods: This study was performed at the Interventional Nephrology Center at Kasr Al-Ainy University Hospitals. Epidemiological data of patients, e.g., age, gender, as well as the number of previously cannulated central veins, were documented. Results: Data of 188 patients with multiple dialysis venous access failure (117 females and 71 males, aged 17–56 years) were collected. Successful innominate (brachiocephalic) venous cannulation was achieved in 149 patients (79%). Eighteen patients had successful external iliac venous approach (9%). Successful transhepatic venous approach was placed as permanent access in 7 patients (4%). The rest of the patients (n = 14, 7%) were referred to other centers due to failure. Conclusions: Sophisticated central venous approaches, mainly brachiocephalic, as described in this study, may play as alternatives for placing either temporary or tunneled hemodialysis catheters in patients with multiple vascular access failure and stenosed or thrombosed central veins.