compared to D230N-Tm mice. No changes were seen in maximal Ca 2þ -activated force. We will next examine Ca 2þ handling in isolated cardiomyocytes. In conclusion, introducing a mutation with stronger Ca 2þ binding can successfully overcome the decrease in Ca 2þ sensitivity at SL 2.0 and 2.3mm caused by the D230N-Tm DCM mutation.
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