this compound was still potent against 5-HT. Since quantitative aspects of this interaction were not studied, suggestions regarding the relation of cholinergic stimulation to 5-HT blockade produced by the same agent at the ganglia cannot be made. When cholinergic stimulation and blockade of the ganglia is produced by different specific agents (i.e., DMIIP or hexamethonium), and stimulation and blockade of the 5-1 IT receptors by other distinct agents {i.e. 5-HT and 5 hydroxy-3-indoleacetamidine), a clear separation of effects regarding stimulation as well as blockade can be obtained between the two different types of ganglionic receptors. Thus, their independence from each other can be established. The situation with molecules which combine cholinergic and 5-HT-like ganglionic stimulant properties (i.e., bufotenine)16 or cholinergic stimulant and 5-HT blocking properties (members of the present series) is not so clear. It is obvious that-further studies arc needed in order to clarify certain points in the ganglionic action of this novel type of agents. Some members of the above series proved to be tInmost potentagents of their class, and, therefore, in spite of their incompletely known mode of act-ion, will merit-further interest as pharmacological tools.
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