No abstract

SUMMARYSomatostatin is a potent inhibitor of endocrine and exocrine pancreatic secretion. However, it is not clear whether it also inhibits pancreatic growth. Therefore we treated male Wistar rats with a somatostatin analogue, octreotide ,tg/(kg body wt.day)), over a period of 14 days. In a dose-dependent manner, this potent and long-acting analogue caused a reduction in weight of the pancreas and a reduction in pancreatic content of protein, DNA, trypsin, chymotrypsin, amylase and lipase, as well as pancreatic content of insulin-, glucagon-and somatostatin-like immunoreactivities. When growth of rat pancreas was induced by oral administration of camostate (200 mg/(kg body wt.day) or by subcutaneous administration of cholecystokinin (2 x 10 /tg/(kg body wt.day)) over a period of 14 days, octreotide ,ug/(kg body wt.day)) had the same effects, but these were even more pronounced. We conclude that somatostatin is an important regulator of pancreatic growth.

No abstract

This paper covers the activities of the working party on Requirements for Fatigue Testing Machines [3]. Requirements and recommendations are specified with respect to the alignment of load frames for fatigue testing, including load cell and (hydraulic) actuator. Subsequently, a method is proposed to measure the alignment errors. Calculations are made and a series of alignment specimens are designed for load frames of different capacities to check whether or not the bending stresses under load, due to misalignment, correlate with the off-load measured alignment errors. Designs for clamping the alignment specimens are given and applied for the measurements as well. The alignment errors to be specified, defined, and measured include: 1. Eccentricity. 2. Angular deflection. 3. Alignment error. Although a literature survey was carried out, there appeared to be no specific requirements for the alignment accuracy of load frames. International standards mainly set out requirements concerning the accuracy of the load cell and the maximum allowable specimen bending at zero load. These standards, however, have omitted the effect of the alignment errors as defined in this paper. Results of measurements obtained with the described method lead to a recommendation for its application, either in part or in total.