The study was done in accordance with the Declaration of Helsinki, and all patients and controls gave written informed consent to participate to the study.Differences in mean values between patients and controls were analysed using Student's t-test (P < 0.05). Pearson correlation coefficient was used to evaluate a linear correlation between ECP and PASI.We found significant higher levels of IgE (27% vs. 4%, P < 0.001) and of ECP (20.5 µg/L vs. 8 µg/L, P < 0.01) in psoriatic patients compared with controls. Patients with increased IgE concentrations showed also high levels of ECP.A significant linear correlation between serum ECP levels and disease activity (PASI) with a Pearson value of 0.924 (P < 0.0001) was found ( fig. 1).None of psoriatics or controls were positive at the PRICK test.Seven per cent (4 of 55) of psoriatic patients showed a PATCH test positivity: 2 for nickel and 2 for chrome. None of the controls resulted positive.Eighteen per cent (10 of 55) of psoriatic patients showed a positivity of the RAST test: 2 pts for egg yolk, 1 for egg white, 2 for α-lactoalbumin, 1 for fish and tomatoes, 1 for milk and 3 for inhalants. Only one of the controls resulted positive to the test for tomatoes.Preliminary results show that the skin lesions improved substantially in patients positive for the PRICK test, for the PATCH test or for RAST, after elimination of the allergens from the diet.Taken together, these data indicate an important alteration of the immunological system in psoriasis, mimicking some of the alterations found in atopic subjects. Improvement of the skin lesions in psoriatic and allergic individuals after elimination of allergens suggests common pathogenetic pathways.The exact role of serum IgE and ECP should be further investigated, but the identification of a subgroup of psoriatic pts who can benefit from specific treatments could be useful in the management of psoriasis. References1 Krueger G, Ellis CN. Psoriasis -recent advances in understanding its pathogenesis and treatment. J Am Acad Dermatol 2005; 53 (1 Suppl): S94-100. 2 Matsuda H, Watanabe N, Geba GP et al. Development of atopic dermatitis-like skin lesion with IgE hyperproduction in NC/Nga mice. International Immunol 1997; 9: 461. 3 Li LF, Sujan SA, Yang H, Wang WH. Serum immunoglobulins in psoriatic erythroderma. Clin Exp Dermatol 2005; 30: 125-127. 4 Kim TY, Park HJ, Kim CW. Eosinophil cationic protein [ECP] level and its correlation with eosinophil number or IgE level of peripheral blood in pts with various skin diseases. J Dermatol Sci 1997; 15: 89-94. 5 Gebhardt M, Wenzel HC, Hipler UC, Herrmann D, Wollina U. Monitoring of serologic immune parameters in inflammatory skin diseases. EditorScleromyxedema is the generalized papular and sclerodermoid form of lichen myxedematosus, associated with monoclonal gammopathy and systemic, even lethal, manifestations. 1 Almost 50 years on from thalidomide worldwide withdrawal for its teratogenic effects, this powerful immunomodulatory agent is currently undergoing a promissor renaissance. Altho...
Durante a época do Verão, as lesões cutâneas que surgem na praia são um motivo frequente de recurso aos serviços de urgência e de consulta de dermatologia. Os autores descrevem o caso de uma criança com uma lesão maculopapular dolorosa que resultou de um provável contato com uma caravela-portuguesa. Não apresentava outros sinais ou sintomas pelo que foi medicada em ambulatório com analgesia, anti-histamínico e corticoide tópico. Após uma semana de evolução constatou-se resolução completa das lesões cutâneas. Apesar da gravidade da maioria dos casos de dermatoses marítimas encontradas em Portugal ser ligeira, considera-se ser importante o estudo da fauna e da flora de cada região para adequar os cuidados terapêuticos.
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